Impact and risk factors of craniofacial malformations in a Colombian population
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Fecha
2009-07-14Autor(es)
Zarante Montoya, Ignacio ManuelLópez, María Andrea
Caro, Mario Andrés
Garcıía Reyes, Juan Camilo
Ospina, Juan Camilo
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Tipo
Artículo de revista
ISSN
0165-5876 / 1872-8464 (Electrónico)
Páginas
1434-1437
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Abstract
Objective: Craniofacial malformations comprise diverse diagnoses, implying a wide range of morbidity and disability among populations. Our aim was to study them as a group and describe their epidemiological factors inside a population as well as finding common risk factors for their presentation in Colombia.
Methods: Wc conducted a case-control study in sevcral Colombian hospitals participating in thc ECLAMC (Spanish acronym for Latin-Amcrican Collaborativc Study of Congcnital Malformations) program. For thc analysis wc includcd 374 cases of isolatcd malformations and 728 Controls, out of 44,701 births.
Results: A rale of83.67 cases per 10,000 births was found for craniofacial malformations as a group, with an overall sex ratio of 1. We found predominance for their presentation on the right side. As main associations we obtained a positive family history of another craniofacial malformation (OR: 3.10 CI95% |2.24-4.30|), particularly preauricular tags (OR 52.36 CI 95% [12.62-217.16]), preauricular pits (OR: 36.35 CI 95% [4.82-274.27]) and cleft lip with or without palate (OR: 2.50 CI 95% [1.07-5.84]). Medication use during pregnancy was also linked to malformations (OR: 2.00 CI 95% [1.38-2.89]). Specific agents such as ferrous sulfate (OR: 1.46 CI 95% [1.13-1.89]), folie acid (OR: 1.35 CI 95% [1.02-1.79]) and nifedipine (OR: 2.88 CI 95% [1.22-6.79]) also showed a significant correlation. Maternal alcohol use was also identified as a possible risk factor (OR: 2.45 CI 95% [1.39-4.29]).
Conclusions: Craniofacial malformations are frcqucntly cncountcrcd among thc group of congcnital defeets. Whcn thcy present in an isolatcd fashion, familial history is an important risk factor, although somc prenatal factors such as alcohol and somc mcdications may have influcncc over their prcvalcncc.
Enlace al recurso
https://www-clinicalkey-es.ezproxy.javeriana.edu.co/#!/content/journal/1-s2.0-S0165587609003838Fuente
International Journal of Pediatric Otorhinolaryngology; Vol. 73 Núm. 10 (2009)
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