2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
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Datum
2014-06-17Autoren
Li, JingmeiLindström, Linda S.
Foo, Jia N.
Rafiq, Sajjad
Schmidt, Marjanka K.
Pharoah, Paul D. P.
Michailidou, Kyriaki
Dennis, Joe
Bolla, Manjeet K.
Wang, Qin
Van‘t Veer, Laura J.
Cornelissen, Sten
Rutgers, Emiel
Southey, Melissa C.
Apicella, Carmel
Dite, Gillian S.
Hopper, John L.
Fasching, Peter A.
Haeberle, Lothar
Ekici, Arif B.
Beckmann, Matthias W.
Blomqvist, Carl
Muranen, Taru A.
Aittomäki, Kristiina
Lindblom, Annika
Margolin, Sara
Mannermaa, Arto
Kosma, Veli-Matti
Hartikainen, Jaana M.
Kataja, Vesa
Chenevix-Trench, Georgia
kConFab Investigators
Phillips, Kelly-Anne
McLachlan, Sue-Anne
Lambrechts, Diether
Thienpont, Bernard
Smeets, Ann
Wildiers, Hans
Chang-Claude, Jenny
Flesch-Janys, Dieter
Seibold, Petra
Rudolph, Anja
Giles, Graham G.
Baglietto, Laura
Severi, Gianluca
Haiman, Christopher A.
Henderson, Brian E.
Schumacher, Fredrick
Marchand, Loic Le
Kristensen, Vessela
Grenaker Alnæs, Grethe I.
Borresen-Dale, Anne-Lise
Nord, Silje
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Andrulis, Irene L.
Knight, Julia A.
Glendon, Gord
Tchatchou, Sandrine
Devilee, Peter
Tollenaar, Robert
Seynaeve, Caroline
Hooning, Maartje
Kriege, Mieke
Hollestelle, Antoinette
Van Den Ouweland, Ans
Li, Yi
Hamann, Ute
Torres, Diana
Ulmer, Hans U.
Rüdiger, Thomas
Shen, Chen-Yang
Hsiung, Chia-Ni
Wu, Pei-Ei
Chen, Shou-Tung
Teo, Soo Hwang
Mohd Taib, Nur Aishah
Yip, Cheng Har
Ho, Gwo Fuang
Matsuo, Keitaro
Ito, Hidemi
Iwata, Hiroji
Tajima, Kazuo
Kang, Daehee
Choi, Ji-Yeob
Park, Sue K.
Yoo, Keun-Young
Maishman, Tom
Tapper, William J.
Dunning, Alison
Shah, Mitul
Luben, Robert
Brown, Judith
Khor, Chiea Chuen
Eccles, Diana M.
Nevanlinna, Heli
Easton, Douglas
Humphreys, Keith
Liu, Jianjun
Hall, Per
Czene, Kamila
Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Typ
Artículo de revista
ISSN
2041-1723 (Electrónico)
Seiten
1-9
Artikeltyp
Artículo original
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Abstrakt
Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49–2.19); P for trend=1.90 × 10−9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.
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https://www.nature.com/articles/ncomms5051#article-infoHerkunft
Nature Communications; Vol. 5 (2014)
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