Hypoglycemia incidence and factors associated in a cohort of patients with type 2 diabetes hospitalized in general ward treated with basal bolus insulin regimen assessed by continuous glucose monitoring
Öffnen
Datum
2019-01-24Autoren
Gómez, Ana MaríaImitola Madero, Angélica
Henao-Carrillo, Diana Cristina
Rondón, Martín
Muñoz, Oscar Mauricio
Robledo, Maria Alejandra
Rebolledo Del Toro, Martin
García Jaramillo, Maira
León Vargas, Fabian
Umpierrez, Guillermo
Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística
Typ
Artículo de revista
ISSN
1932-2968 (Electrónico)
Seiten
233-239
Artikeltyp
Artículo original
Teile diesen Datensatz
Citación
Metadata
Zur Langanzeige
PDF-Dokumente
Abstrakt
Introduction:
Continuous glucose monitoring (CGM) is a better tool to detect hyper and hypoglycemia than capillary point of care in insulin-treated patients during hospitalization. We evaluated the incidence of hypoglycemia in patients with type 2 diabetes (T2D) treated with basal bolus insulin regimen using CGM and factors associated with hypoglycemia.
Methods:
Post hoc analysis of a prospective cohort study. Hypoglycemia was documented in terms of incidence rate and percentage of time <54 mg/dL (3.0 mmol/L) and <70 mg/dL (3.9 mmol/L). Factors evaluated included glycemic variability analyzed during the first 6 days of basal bolus therapy.
Results:
A total of 34 hospitalized patients with T2D in general ward were included, with admission A1c of 9.26 ± 2.62% (76.8 ± 13 mmol/mol) and mean blood glucose of 254 ± 153 mg/dL. There were two events of hypoglycemia below 54 mg/dL (3.0 mmol/L) and 11 events below 70 mg/dL (3.9 mmol/L) with an incidence of hypoglycemic events of 0.059 and 0.323 per patient, respectively. From second to fifth day of treatment the percentage of time in range (140-180 mg/dL, 7.8-10.0 mmol/L) increased from 72.1% to 89.4%. Factors related to hypoglycemic events <70 mg/dL (3.9 mmol/L) were admission mean glucose (IRR 0.86, 95% CI 0.79, 0.95, P < .01), glycemic variability measured as CV (IRR 3.12, 95% CI 1.33, 7.61, P < .01) and SD, and duration of stay.
Conclusions:
Basal bolus insulin regimen is effective and the overall incidence of hypoglycemia detected by CGM is low in hospitalized patients with T2D. Increased glycemic variability as well as the decrease in mean glucose were associated with events <70 mg/dL (3.9 mmol/L).
Verknüpfen Sie mit der Ressource
https://journals-sagepub-com.ezproxy.javeriana.edu.co/doi/full/10.1177/1932296818823720Herkunft
Journal of Diabetes Science and Technology; Vol. 14 Núm. 2 (2020)
Google Analytics Statistics
Collections
- Artículos [682]