First symptoms and neurocognitive correlates of behavioral variant frontotemporal dementia
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Datum
2016-06-22Autoren
Santamaría García, HernandoReyes Gavilán, Pablo Alexander
García, Adolfo
Báez Buitrago, Sandra Jimena
Martínez, Ángela
Santacruz, José Manuel
Slachevsky Chonchol, Andrea María
Sigman, Mariano
Matallana Eslava, Diana Lucía
Ibañez, Agustín
Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
Typ
Artículo de revista
ISSN
1387-2877
Seiten
957-970
Artikeltyp
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Englischer Titel
First symptoms and neurocognitive correlates of behavioral variant frontotemporal dementiaAbstrakt
Background: Previous works highlight the neurocognitive differences between apathetic and disinhibited clinical presentations of the behavioral variant frontotemporal dementia (bvFTD).However, little is knownregarding howthe early presentation (i.e., first symptom) is associated to the neurocognitive correlates of the disease’s clinical presentation at future stages of disease.
Objectives: We analyzed the neurocognitive correlates of patients with bvFTD who debuted with apathy or disinhibition as first symptom of disease.
Methods: We evaluated the neuropsychological, clinical, and neuroanatomical (3T structural images) correlates in a group of healthy controls (n = 30) and two groups of bvFTD patients (presented with apathy [AbvFTD, n = 18] or disinhibition [DbvFTD, n = 16]). To differentiate groups according to first symptoms, we used multivariate analyses.
Results: The first symptom in patients described the evolution of the disease. AbvFTD and DbvFTD patients showed increased brain atrophy and increased levels of disinhibition and apathy, respectively. Whole brain analyzes in AbvFTD revealed atrophy in the frontal, insular, and temporal areas. DbvFTD, in turn, presented atrophy in the prefrontal regions, temporoparietal junction, insula, and temporoparietal region. Increased atrophy in DbvFTD patients (compared to AbvFTD) was observed in frontotemporal regions. Multivariate analyses confirmed that a set of brain areas including right orbitofrontal, right dorsolateral prefrontal, and left caudate were enough to distinguish the patients’ subgroups.
Conclusion: First symptom in bvFTD patients described the neurocognitive impairments after around three years of disease, playing an important role in the early detection, disease tracking, and neuroanatomical specification of bvFTD, as well as in future research on potential disease-modifying treatments.
Keywords
ApathyBehavioral variant frontotemporal dementia
Disinhibition
Apathy
First symptom
Voxel-based morphometry
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https://www.researchgate.net/publication/305083955_First_Symptoms_and_Neurocognitive_Correlates_of_Behavioral_Variant_Frontotemporal_DementiaHerkunft
Journal of Alzheimer's Disease; Vol. 54 (2016)
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