Impact of sensor-augmented pump therapy with predictive low-glucose management on hypoglycemia and glycemic control in patients with type 1 diabetes mellitus : 1-year follow-up
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Fecha
2019-07-10Autor(es)
Gómez, Ana MaríaHenao, Diana C.
Leguizamón, Guillermo
Rondón, Martín A.
Muñoz, Oscar
García Jaramillo, María A.
León Vargas, Fabián
Taboada, Lucía B.
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística
Tipo
Artículo de revista
ISSN
18780334 / 18714021 (Electrónico)
Páginas
2625-2631
Tipo de artículo
Artículo original
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Abstract
AIMS:
To describe real-life experience with sensor-augmented pump therapy with predictive low-glucose management (SAPT-PLGM), in terms of hypoglycemia and glycemic control after one year of follow-up in T1D patients with hypoglycemia as the main indication of therapy.
METHODS:
Retrospective cohort study under real life conditions. Baseline and one-year follow-up variables of glycemic control, hypoglycemia and glycemic variability were compared.
RESULTS:
Fifty patients were included, 31 on prior treatment with SAPT with low-glucose suspend (LGS) feature and 19 on multiple dose insulin injections (MDI). Mean HbA1c decreased in the MDI group (8.24%-7.08%; p = 0.0001). HbA1c change was not significant in the SAPT-LGS group. Area under the curve (AUC) below 70 mg/dl improved in both SAPT-LGS and MDI groups while AUC, %time and events below 54 mg/dl decreased in SAPT-LGS group. Glycemic variability improved in the MDI group. Less patients presented severe hypoglycemia with SAPT-PLGM in both groups, however the change was non-significant.
CONCLUSIONS:
Under real life conditions, SAPT-PLGM reduced metrics of hypoglycemia in patients previously treaded with MDI and SAPT-LGS without deteriorating glycemic control in SAPT-LGS patients, while improving it in patients treated with MDI.
Keywords
Diabetes mellitusGlycated hemoglobin A
Hypoglycemia
Insulin infusion systems
Sensor-augmented pump therapy
Type 1
Fuente
Diabetes and Metabolic Syndrome: Clinical Research and Reviews; Vol. 13 Núm. 4 (2019)
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