Pharmacologic interventions to treat renal colic pain in acute stone episodes : Systematic review and meta-analysis
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2017-06-23Autor(es)
García-Perdomo, H. A.Echeverría-García, F.
López, H.
Fernández, José Nicolás
Manzano-Núñez, Ramiro
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Cirugía y Especialidades. Grupo de Investigación de Cirugía y Especialidades
Tipo
Artículo de revista
ISSN
1166-7087
Páginas
654-665
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Título alternativo
Interventions pharmacologiques pour traiter la douleur colique rénale dans les épisodes aigus de la pierre : revue systématique et méta-analyseAbstract
Summary
Objective
To assess effectiveness of pharmacologic interventions to relieve pain in patients suffering an acute stone episode.
Methods
Relevant trials that included patients with acute renal colic and radiological findings of urinary stones were identified in four databases. The main outcome was pain relief evaluated by Visual Analogue Scale score (VAS).
Results
In overall, diclofenac was superior to other NSAIDs for pain relief (MD of −12.57 [95% CI: −19.26, −5.88]). Paracetamol was superior to morphine for pain reduction at 30 minutes (MD of −3.92 [95% CI: −6.41, −1.43]) and also to placebo at 15 minutes (MD of −24.77 [95% CI: −33.19, −16.35]) and at 30 minutes (MD of −16 [95% CI:−29, −2.96]) after drug administration. Finally, diclofenac was superior to paracetamol for pain reduction at 60 (MD of 6.60 [95% CI: 4.37, 8.83]) and 90 minutes (MD of 3.4 [95% CI: 2.01, 4.79]).
Conclusions
Diclofenac was superior to other NSAIDs and paracetamol for diminishing pain in patients suffering an acute stone episode. Paracetamol was superior to morphine and placebo for short pain relief. Future trials should address the role of paracetamol in the management of pain in patients suffering an acute stone episode.
Link para o recurso
https://www.sciencedirect.com/science/article/pii/S1166708717301288?via%3Dihub#!Fonte
Progrès en Urologie; Vol. 27 Núm. 2 (2017)
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