Visceral, subcutaneous abdominal adiposity and liver fat content distribution in normal glucose tolerance, impaired fasting glucose and/or impaired glucose tolerance
Voir/ Ouvrir
Date
2015-09-02Les auteurs
Borel, A. L.Nazare, J. A.
Smith, J.
Aschner Montoya, Pablo
Barter, Phil
Van Gaal, Luc
Eng Tan, Chee
Wittchen, Hans-Ulrich
Matsuzawa, Yuji
Kadowaki, Takashi
Ross, Robert
Brulle Wohlhueter, C.
Alméras, N.
Haffner, Steven M.
Balkau, Beverley
Després, Jean Pierre
Auteur(s) d'entreprise
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Endocrinología
Type
Artículo de revista
ISSN
0307-0565 / 1476-5497 (Electrónico)
Partager cet enregistrement
Citación
Metadata
Afficher la notice complète
Documents PDF
Abstrait
Objectives:
To examine the specific distribution of liver fat content, visceral and subcutaneous adiposity in normal glucose tolerance (NGT/NGT), isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT) and combined conditions (IFG+IGT), as well as with newly diagnosed type 2 diabetes (nT2D).
Design:
Multicenter, international observational study: cross-sectional analysis.
Subjects:
Two thousand five hundred and fifteen patients (50.0% women, 54.5% non-Caucasian) without previously known diabetes were recruited from 29 countries. Abdominal fat distribution was measured by computed tomography (CT). Liver fat was estimated using the CT-liver mean attenuation.
Results:
Compared with NGT/NGT patients, increased visceral adiposity was found in iIFG, iIGT, IFG+IGT and nT2D; estimated liver fat progressively increased across these conditions. A one-s.d. increase in visceral adiposity was associated with an increased risk of having iIFG (men: odds ratio (OR) 1.41 (95% confidence interval (CI) 1.15–1.74), women: OR 1.62 (1.29–2.04)), iIGT (men: OR 1.59 (1.15–2.01), women: OR 1.30 (0.96–1.76)), IFG+IGT (men: OR 1.64 (1.27–2.13), women: OR 1.83 (1.36–2.48)) and nT2D (men: OR 1.80 (1.35–2.42), women: OR 1.73 (1.25–2.41)). A one-s.d. increase in estimated liver fat was associated with iIGT (men: OR 1.46 (1.12–1.90), women: OR 1.81 (1.41–2.35)), IFG+IGT (men: OR 1.42 (1.14–1.77), women: OR 1.74 (1.35–2.26)) and nT2D (men: OR 1.77 (1.40–2.27), women: OR 2.38 (1.81–3.18)). Subcutaneous abdominal adipose tissue showed an inverse relationship with nT2D in women (OR 0.63 (0.45–0.88)).
Conclusions:
Liver fat was associated with iIGT but not with iIFG, whereas visceral adiposity was associated with both. Liver fat and visceral adiposity were associated with nT2D, whereas subcutaneous adiposity showed an inverse relationship with nT2D in women.
Lien vers la ressource
https://www.nature.com/articles/ijo2014163Origine
International Journal of Obesity; Volumen 39 Número 3 , Páginas 495 - 501 (2015)
Google Analytics Statistics
Collections
- Artículos [56]