The Latin American network for congenital malformation surveillance : ReLAMC
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Date
2020-12-02Authors
Orioli, Iêda MariaDolk, Helen
Lopez-Camelo, Jorge
Groisman, Boris
Benavides-Lara, Adriana
Gimenez, Lucas Gabriel
Mattos Correa, Daniel
Ascurra, Marta
de Aquino Bonilha, Eliana
Canessa-Tapia, Maria Aurora
Araújo de França, Giovanny Vinícius
Hurtado-Villa, Paula
Ibarra-Ramírez, Marisol
Pardo, Rosa
Pastora, Dania Maria
Zarante, Ignacio
Schneider Soares, Flávia
Martinez de Carvalho, Flávia
Piola, Mariana
Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
ReLAMC Group
Type
Artículo de revista
ISSN
15524876 / 15524868
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Abstract
The early detection of congenital anomaly epidemics occurs when comparing current with previous frequencies in the same population. The success of epidemiologic surveillance depends on numerous factors, including the accuracy of the rates available in the base period, wide population coverage, and short periodicity of analysis. This study aims to describe the Latin American network of congenital malformation surveillance: ReLAMC, created to increase epidemiologic surveillance in Latin America. We describe the main steps, tasks, strategies used, and preliminary results. From 2017 to 2019, five national registries (Argentina [RENAC], Brazil [SINASC/SIM-BRS], Chile [RENACH], Costa Rica [CREC], Paraguay [RENADECOPY-PNPDC]), six regional registries (Bogotá [PVSDC- Bogota], Cali [PVSDC-Cali], Maule [RRMC SSM], Nicaragua [SVDC], Nuevo-León [ReDeCon HU], S~ao Paulo [SINASC/SIM-MSP]) and the ECLAMC hospital network sent data to ReLAMC on a total population of 9,152,674 births, with a total of 101,749 malformed newborns (1.1%; 95% CI 1.10–1.12). Of the 9,000,651 births in countries covering both live and stillbirths, 88,881 were stillborn (0.99%; 95% CI 0.98–0.99), and among stillborns, 6,755 were malformed (7.61%; 95% CI 7.44–7.79). The microcephaly rate was 2.45 per 10,000 births (95% CI 2.35–2.55), hydrocephaly 3.03 (2.92–3.14), spina bifida 2.89 (2.78–3.00), congenital heart defects 15.53 (15.27–15.79), cleft lip 2.02 (1.93–2.11), cleft palate and lip 2.77 (2.66–2.88), talipes 2.56 (2.46–2.67), conjoined twins 0.16 (0.14–0.19), and Down syndrome 5.33 (5.18–5.48). Each congenital anomaly showed heterogeneity in prevalence rates among registries. The harmonization of data in relation to operational differences between registries is the next step in developing the common ReLAMC database.
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https://doi-org.ezproxy.javeriana.edu.co/10.1002/ajmg.c.31872Source
American Journal of Medical Genetics, Part C: Seminars in Medical Genetics; Volumen 184 Número 4 , Páginas 1078 - 1091 (2020)
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