A common coding variant in CASP8 is associated with breast cancer risk
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2007-02-11Autor(es)
Cox, AngelaDunning, Alison M.
Garcia-Closas, Montserrat
Balasubramanian, Sabapathy
Reed, Malcolm W. R.
Pooley, Karen A.
Scollen, Serena
Baynes, Caroline
Ponder, Bruce A. J.
Chanock, Stephen
Lissowska, Jolanta
Brinton, Louise
Peplonska, Beata
Southey, Melissa C.
Hopper, John L.
McCredie, Margaret R. E.
Giles, Graham G.
Fletcher, Olivia
Johnson, Nichola
dos Santos Silva, Isabel
Gibson, Lorna
Bojesen, Stig E.
Nordestgaard, Børge G.
Axelsson, Christen K.
Torres, Diana
Hamann, Ute
Justenhoven, Christina
Brauch, Hiltrud
Chang-Claude, Jenny
Kropp, Silke
Risch, Angela
Wang-Gohrke, Shan
Schürmann, Peter
Bogdanova, Natalia
Dörk, Thilo
Fagerholm, Rainer
Aaltonen, Kirsimari
Blomqvist, Carl
Nevanlinna, Heli
Seal, Sheila
Renwick, Anthony
Stratton, Michael R.
Rahman, Nazneen
Sangrajrang, Suleeporn
Hughes, David
Odefrey, Fabrice
Brennan, Paul
Spurdle, Amanda B.
Chenevix-Trench, Georgia
The Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer
Beesley, Jonathan
Mannermaa, Arto
Hartikainen, Jaana
Kataja, Vesa
Kosma, Veli-Matti
Couch, Fergus J.
Olson, Janet E.
Goode, Ellen L.
Broeks, Annegien
Schmidt, Marjanka K.
Hogervorst, Frans B. L.
Veer, Laura J. Van't
Kang, Daehee
Yoo, Keun-Young
Noh, Dong-Young
Ahn, Sei-Hyun
Wedrén, Sara
Hall, Per
Low, Yen-Ling
Liu, Jianjun
Milne, Roger L.
Ribas, Gloria
Gonzalez-Neira, Anna
Benitez, Javier
Sigurdson, Alice J.
Stredrick, Denise L.
Alexander, Bruce H.
Struewing, Jeffery P.
Pharoah, Paul D. P.
Easton, Douglas F.
Breast Cancer Association Consortium
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Tipo
Artículo de revista
ISSN
1061-4036 / 1546-1718 (Electrónico)
Páginas
352-358
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Abstract
The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 −202 C → A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3′ UTR A → G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9–15 studies, comprising 11,391–18,290 cases and 14,753–22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85–0.94) and 0.74 (95% c.i.: 0.62–0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; Ptrend = 1.1 × 10−7) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02–1.13) and 1.16 (95% c.i.: 1.08–1.25), respectively; Ptrend = 2.8 × 10−5). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies.
Enlace al recurso
https://search-proquest-com.ezproxy.javeriana.edu.co/docview/222632891/3A78E68EEE254DCAPQ/19?accountid=13250Fuente
Nature Genetics; Vol. 39 Núm. 3 (2007)
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