Immunomodulators released during rotavirus infectionof polarized caco-2 cells
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Datum
2009-02-18Autoren
Rodríguez Camacho, Luz StellaBarreto Prieto, Alfonso
Franco Cortés, Manuel Antonio
Ángel Uribe, Juanita
Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Typ
Artículo de revista
ISSN
0882-8245 / 1557-8976 (Electrónico)
Seiten
163-172
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Abstrakt
Rotavirus preferentially replicates in enterocytes and "danger signals" released by these cells are likely to modulate viral immunity. As a model of these events, we studied selected immunomodulators released during rotavirus infection of polarized Caco-2 cells grown in transwell cultures (TW). At early time points post-infection the virus was detected mainly in the apical side of the TWs, but this tendency was progressively lost concomitantly with disruption of the cell monolayer and cell death. Rotavirus-infected cells released IL-8, PGE[sub]2, small quantities of TGF-β1, and the constitutive and inducible heat shock proteins HSC70 and HSP70, but not IL-1β, IL-6, IL-10, IL-12p70, or TNF-α. This set of immunomodulators is known to induce a non-inflammatory (non-Th-1) immune response, and may be determining, in part, the relatively low T-cell immune response observed in blood samples after RV infection.
Keywords
Caco-2 CellsVerknüpfen Sie mit der Ressource
https://search-proquest-com.ezproxy.javeriana.edu.co/docview/219482764/B4E11FE1DF034B6BPQ/3?accountid=13250Herkunft
Viral Immunology; Vol. 22 Núm. 3 (2009)
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