Rotavirus immune responses and correlates of protection
AuthorsPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Ángel Uribe, Juanita
Franco Cortés, Manuel Antonio
Greenberg, Harry B.
1879-6257 / 1879-6265 (Electrónico)
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English TitleRotavirus immune responses and correlates of protection
Selected topics in the field of rotavirus immunity are reviewed focusing on recent developments that may improve efficacy and safety of current and future vaccines. Rotaviruses have developed multiple mechanisms to evade interferon-mediated innate immunity. Compared to more developed regions of the world, protection induced by natural infection and vaccination is reduced in developing countries where, among other factors, high viral challenge loads are common and where infants are infected at an early age. Studies in developing countries indicate that rotavirusspecific serum IgA levels are not an optimal correlate of protection following vaccination, and better correlates need to be identified. Protection against rotavirus following vaccination is substantially heterotypic; nonetheless, a role for homotypic immunity in selection of circulating post vaccination strains needs further study.
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Link to the resourcehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422408/
SourceCurrent Opinion in Virology; Vol. 2 Núm. 4 (2012)
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