Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer
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2015-01-13Autore
Tórres López, Diana MaríaKabisch, Maria
Bermejo, Justo Lorenzo
Duennebier, Thomas
Ying, Shibo
Michailidou, Kyriaki
Bolla, Manjeet K.
Wang, Qin
Dennis, Joe
Shah, Mitul
Perkins, Barbara J.
Czene, Kamila
Darabi, Hatef
Eriksson, Mikael
Bojesen, Stig Egil
Nordestgaard, Borge G.
Nielsen, Sune Fallgaard
Flyger, Henrik
Lambrechts, Diether
Neven, Patrick
Peeters, Stephanie
Weltens, Caroline
Couch, Fergus J.
Olson, Janet E.
Wang, Xianshu
Purrington, Kristen
Rudolph, Anja
Seibold, Petra
Peto, Julian
Johnson, Nichola
Fletcher, Olivia
Nevanlinna, Heli
Muranen, Taru Annika
Aittomaki, Kristiina
Blomqvist, Carl
Schmidt, Marjanka K.
Broeks, Annegien
Cornelissen, Sten
Hogervorst, Frans B. L.
Li, Jingmei
Brand, Judith S.
Humphreys, Keith
Guenel, Pascal
Truong, Therese
Menegaux, Florence
Sanchez, Marie
Burwinkel, Barbara
Marme, Frederik
Yang, Rongxi
Bugert, Peter
Gonzalez-Neira, Anna
Benitez, Javier
Zamora Auñón, María del Pilar
Arias Perez, Jose Ignacio
Cox, Angela
Cross, Simon S.
Reed, Malcolm W. R.
Andrulis, Irene L.
Knight, Julia Alexandra
Glendon, Gord
Tchatchou, Sandrine
Sawyer, Elinor J.
Tomlinson, Ian
Kerin, Michael J.
Miller, Nicola
Haiman, Christopher A.
Schumacher, Fredrick
Henderson, Brian E.
Le Marchand, Loic
Lindblom, Annika
Margolin, Sara
Hooning, Maartje J.
Hollestelle, Antoinette
Kriege, Mieke
Koppert, Linetta B.
Hopper, John L.
Southey, Melissa C.
Tsimiklis, Helen
Apicella, Carmel
Slettedahl, Seth Seth
Toland, Amanda E.
Vachon, Celine
Yannoukakos, Drakoulis
Giles, Graham G.
Milne, Roger L.
McLean, Catriona
Fasching, Peter A.
Ruebner, Matthias
Ekici, Arif Bülent
Beckmann, Matthias W.
Brenner, Hermann
Dieffenbach, Aida Karina
Arndt, Volker
Stegmaier, Christa
Ashworth, Alan
Orr, Nicholas
Schoemaker, Minouk J.
Swerdlow, Anthony
Figueroa, Jonine
Chanock, Stephen Jacob
Lissowska, Jolanta
Goldberg, Mark S.
Labreche, France
Dumont, Martine
Winqvist, Robert
Pylkas, Katri
Grip, Mervi
Brauch, Hiltrud
Bruening, Thomas
Chang Claude, Jenny
Flesch Janys, Dieter
dos Santos Silva, Isabel
Garcia Closas, Montserrat
Jukkola Vuorinen, Arja
Ko, Yon-Dschun
Radice, Paolo
Peterlongo, Paolo
Scuvera, Giulietta
Fortuzzi, Stefano
Bogdanova, Natalia
Doerk, Thilo
Mannermaa, Arto
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M.
Devilee, Peter
Tollenaar, Robert A. E. M.
Seynaeve, Caroline
Van Asperen, Christi J.
Jakubowska, Anna
Lubinski, Jan
Jaworska Bieniek, Katarzyna
Durda, Katarzyna
Zheng, Wei
Shrubsole, Martha J.
Cai, Qiuyin
Anton Culver, Hoda
Kristensen, Vessela
Bacot, Francois
Tessier, Daniel C.
Vincent, Daniel
Luccarini, Craig
Baynes, Caroline
Ahmed, Shahana
Maranian, Mel
Simard, Jacques
Chenevix Trench, Georgia
Hall, Per
Pharoah, Paul D. P.
Dunning, Alison M.
Easton, Douglas F.
Hamann, Ute
Autore/i aziendale
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Tipo
Artículo de revista
ISSN
0143-3334 / 1460-2180 (Electrónico)
Pagine
256-271
Tipo di oggetto
Artículo original
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Titolo inglese
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancerAstratto
The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variability could influence tumor development. The present candidate gene approach investigates the relationship between single nucleotide polymorphisms (SNPs) in genes encoding key CPC components and breast cancer risk. Fifteen SNPs in four CPC genes (INCENP, AURKB, BIRC5 and CDCA8) were genotyped in 88 911 European women from 39 case-control studies of the Breast Cancer Association Consortium. Possible associations were investigated in fixed-effects meta-analyses. The synonymous SNP rs1675126 in exon 7 of INCENP was associated with overall breast cancer risk [per A allele odds ratio (OR) 0.95, 95% confidence interval (CI) 0.92–0.98, P = 0.007] and particularly with estrogen receptor (ER)-negative breast tumors (per A allele OR 0.89, 95% CI 0.83–0.95, P = 0.0005). SNPs not directly genotyped were imputed based on 1000 Genomes. The SNPs rs1047739 in the 3ʹ untranslated region and rs144045115 downstream of INCENP showed the strongest association signals for overall (per T allele OR 1.03, 95% CI 1.00–1.06, P = 0.0009) and ER-negative breast cancer risk (per A allele OR 1.06, 95% CI 1.02–1.10, P = 0.0002). Two genotyped SNPs in BIRC5 were associated with familial breast cancer risk (top SNP rs2071214: per G allele OR 1.12, 95% CI 1.04–1.21, P = 0.002). The data suggest that INCENP in the CPC pathway contributes to ER-negative breast cancer susceptibility in the European population. In spite of a modest contribution of CPC-inherited variants to the total burden of sporadic and familial breast cancer, their potential as novel targets for breast cancer treatment should be further investigated.
Keywords
AllelesChromosomes
Genes
Genoty
Single nucleotide polymorphism
Breast cancer
Survivin
Nestrogen receptor negative
Breast cancer risk
Imputation
Neoplasms
Link alla risorsa
https://academic.oup.com/carcin/article/36/2/256/334957Editoriale
Carcinogenesis; Vol. 36 Núm. 2 (2015)
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