RUNX family: oncogenes or tumor suppressors (Review)
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Date
2019-05-06Authors
Otálora Otálora, Beatriz AndreaHenriquez Cabezas, Berta Cristina
López Kleine, Liliana
Rojas, Adriana
Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
Type
Artículo de revista
ISSN
1021-335X / 1791-2431 (Electrónico)
Pages
3 - 19
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Abstract
Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, specific regulatory abilities and experimental evidence of RUNX proteins will be analyzed to demonstrate their oncogenic potential and tumor suppressor abilities during oncogenic processes, suggesting their importance as biomarkers of cancer. Additionally, the importance of continuing with the molecular studies of RUNX proteins' and its dual functions in cancer will be underlined in order to apply it in the future development of specific diagnostic methods and therapies against different types of cancer.
Link to the resource
https://www.spandidos-publications.com/10.3892/or.2019.7149Source
Oncology Reports; Volumen 42 Número 1 (2019)
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