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dc.creatorPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
dc.creatorOtálora Otálora, Beatriz Andrea
dc.creatorHenriquez Cabezas, Berta Cristina
dc.creatorLópez Kleine, Liliana
dc.creatorRojas Moreno, Adriana Patricia
dc.date.accessioned2020-02-27T12:42:38Z
dc.date.accessioned2020-04-15T13:30:34Z
dc.date.available2020-02-27T12:42:38Z
dc.date.available2020-04-15T13:30:34Z
dc.date.created2019-04-11
dc.identifierhttps://www.spandidos-publications.com/10.3892/or.2019.7149spa
dc.identifier.issn1021-335X / 1791-2431 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/47388
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.languageInglésspa
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceOncology Reports; Vol. 42 Núm. 1 (2019)spa
dc.titleRUNX family : oncogenes or tumor suppressors (Review)spa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/draft
dc.description.cuartilWosQ2spa
dc.description.cuartilScopusQ1spa
dc.title.englishRUNX family : oncogenes or tumor suppressors (Review)spa
dc.identifier.doihttps://doi.org/10.3892/or.2019.7149spa
dc.description.paginas3-19spa
dc.format.soportePapel / Electrónicospa
dc.subject.subjectenglishRUNXspa
dc.subject.subjectenglishOncogenesspa
dc.subject.subjectenglishTumor suppressorsspa
dc.description.abstractenglishRunt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, specific regulatory abilities and experimental evidence of RUNX proteins will be analyzed to demonstrate their oncogenic potential and tumor suppressor abilities during oncogenic processes, suggesting their importance as biomarkers of cancer. Additionally, the importance of continuing with the molecular studies of RUNX proteins' and its dual functions in cancer will be underlined in order to apply it in the future development of specific diagnostic methods and therapies against different types of cancer.spa
dc.type.spaArtículospa


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International