Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
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Fecha
2016Autor(es)
Bernal Villegas, Jaime EduardoGomez Bello, Rosa Margarita
Ghotme Ghotme, Kemel Ahmed
Botero Espinosa, Lucia
Perez Castro, Rosalia
Sampaio Barreto, George Emilio
Bustos Cruz, Rosa Helena
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Tipo
Artículo de revista
ISSN
0168-0102 / 1872-8111 (Electrónico)
Páginas
10-17
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Abstract
Olfactory nerve derived and olfactory bulb derived olfactory ensheathing cells (OECs) have the ability to promote axonal regenerationandremyelination, bothof whichare essentialina successful celltransplant. Thus, morphological identification of OECs is a key aspectto develop an applicable celltherapy for injuries to the nervous system. However, there is no clear definition regarding which developmental stage or anatomical origin of OECs is more adequate for neural repair. In the present study, an ultrastructural comparison was made between OECs recovered from primary cultures of olfactory nerve and bulb in two developmental stages. The most notorious difference between cells obtained from olfactory nerve and bulb was the presence of indented nuclei in bulb derived OECs, suggesting a greater ability for possible chemotaxis. In neonatal OECs abundant mitochondria, lipid vacuoles, and smooth endoplasmic reticulum were detected, suggesting an active lipid metabolism, probably involved in synthesis of myelin. Our results suggest that neonatal OECs obtained from olfactory bulb have microscopic properties that could make them more suitable for neural repair
Fuente
Neuroscience Research; Vol. 103 (2016)
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