Rotavirus
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Fecha
2013-12-20Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Tipo
Artículo de revista
ISSN
1678-4405
Páginas
1-10
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Título en inglés
RotavirusAbstract
Rotaviruses (RV) are ubiquitous, highly infectious,
segmented double-stranded RNA genome viruses of importance
in public health because of the severe acute gastroenteritis they
cause in young children and many animal species. They are very
well adapted to their host, with symptomatic and asymptomatic
reinfections being virtually universal during the first 3 years of
life. Antibodies are the major arm of the immune system
responsible for protecting infants from RV reinfection. The
relationship between the virus and the B cells (Bc) that produce
these antibodies is complex and incompletely understood: most
blood-circulating Bc that express RV-specific immunoglobulin
(Ig) on their surface (RV-Ig) are naive Bc and recognize the
intermediate capsid viral protein VP6 with low affinity. When
compared to non-antigen-specific Bc, RV-Bc are enriched in
CD27+ memory Bc (mBc) that express IgM. The Ig genes used by
naive RV-Bc are different than those expressed by RV-mBc,
suggesting that the latter do not primarily develop from the
former. Although RV predominantly infects mature villus
enterocytes, an acute systemic viremia also occurs and RV-Bc
can be thought of as belonging to either the intestinal or
systemic immune compartments. Serotype-specific or
heterotypic RV antibodies appear to mediate protection by
multiple mechanisms, including intracellular and extracellular
homotypic and heterotypic neutralization. Passive
administration of RV-Ig can be used either prophylactically or
therapeutically. A better understanding of the Bc response
generated against RV will improve our capacity to identify
improved correlates of protection for RV vaccines.
Enlace al recurso
https://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.AID-0011-2013Fuente
Microbiology Spectrum; Vol. 1 Núm. 2 (2013)
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