Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry
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Fecha
2016-04-06Autor(es)
Zhao, ZhiguoWen, Wanqing
Michailidou, Kyriaki
Bolla, Manjeet K.
Wang, Qin
Zhang, Ben
Long, Jirong
Shu, Xiao-Ou
Schmidt, Marjanka K.
Milne, Roger L.
Garcı´a-Closas, Montserrat
Chang-Claude, Jenny
Lindstrom, Sara
Bojesen, Stig E.
Ahsan, Habibul
Aittoma¨ki, Kristiina
Andrulis, Irene L.
Anton-Culver, Hoda
Arndt, Volker
Beckmann, Matthias W.
Beeghly-Fadiel, Alicia
Beeghly-Fadiel, Javier
Blomqvist, Carl
Bogdanova, Natalia V.
Børresen-Dale, Anne-Lise
Brand, Judith
Brauch, Hiltrud
Brenner, Hermann
Burwinkel, Barbara
Cai, Qiuyin
Casey, Graham
Chenevix-Trench, Georgia
Couch, Fergus J.
Cox, Angela
Cross, Simon S.
Czene, Kamila
Do¨rk, Thilo
Dumont, Martine
Fasching, Peter A.
Figueroa, Jonine
Flesch-Janys, Dieter
Fletcher, Olivia
Flyger, Henrik
Fostira, Florentia
Gammon, Marilie
Giles, Graham G.
Gue´nel, Pascal
Haiman, Christopher A.
Hamann, Ute
Harrington, Patricia
Hartman, Mikael
Hooning, Maartje J
Hopper, John L.
Jakubowska, Anna
Jasmine, Farzana
John, Esther M.
Johnson, Nichola
Kabisch, Maria
Khan, Sofia
Kibriya, Muhammad
Knight, Julia A.
Kosma, Veli-Matti
Kriege, Mieke
Kristensen, Vessela
Marchand, Loic Le
Lee, Eunjung
Li, Jingmei
Lindblom, Annika
Lophatananon, Artitaya
Luben, Robert
Lubinski, Jan
Malone, Kathleen E.
Mannermaa, Arto
Manoukian, Siranoush
Margolin, Sara
Marme, Frederik
McLean, Catriona
Meijers-Heijboer, Hanne
Meindl, Alfons
Miao, Hui
Muir, Kenneth
Neuhausen, Susan L.
Nevanlinna, Heli
Neven, Patrick
Olson, Janet E.
Perkins, Barbara
Peterlongo, Paolo
Phillips, Kelly-Anne
Pylka¨s, Katri
Rudolph, Anja
Santella, Regina
Sawyer, Elinor J.
Schmutzler, Rita K.
Schoemaker, Minouk
Shah, Mitul
Shrubsole, Martha
Southey, Melissa C.
Swerdlow, Anthony J.
Toland, Amanda E.
Tomlinson, Ian
Torres, Diana
Truong, The´re`se
Ursin, Giske
Van Der Luijt, Rob B.
Verhoef, Senno
Wang-Gohrke, Shan
Whittemore, Alice S.
Winqvist, Robert
Zamora, M. Pilar
Zhao, Hui
Dunning, Alison M.
Simard, Jacques
Hall, Per
Kraft, Peter
Pharoah, Paul
Hunter, David
Easton, Douglas F.
Zheng, Wei
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Tipo
Artículo de revista
ISSN
0957-5243 / 1573-7225 (Electrónico)
Páginas
679-693
Tipo de artículo
Artículo original
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Abstract
PURPOSE:
Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.
METHODS:
We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies.
RESULTS:
The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
CONCLUSIONS:
We have shown that several genetic risk variants were associated with the risk of both T2D and breast cancer. However, overall genetic susceptibility to T2D may not be related to breast cancer risk.
Cobertura espacial
EuropaEnlace al recurso
https://www.ncbi.nlm.nih.gov/pubmed/27053251Fuente
Cancer causes & control; Vol. 27 Núm. 5 (2016)
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