Weighted Symbolic Dependence Metric (wSDM) for fMRI restingstate connectivity : A multicentric validation for frontotemporal dementia

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Date
2018-07-25Authors
Moguilne, SebastianGarcía, Adolfo M.
Mikulan, Ezequiel
Hesse, Eugenia
García-Cordero, Indira
Melloni, Margherita
Cervetto, Sabrina
Serrano, Cecilia
Herrera, Eduar
Reyes, Pablo
Manes, Facundo
Ibáñez, Agustín
Sedeño, Lucas
Matallana Eslava, Diana
Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
Type
Artículo de revista
ISSN
2045-2322 (Electrónico)
Pages
1-15
Item type
Reporte Científico
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English Title
Weighted Symbolic Dependence Metric (wSDM) for fMRI restingstate connectivity : A multicentric validation for frontotemporal dementiaAbstract
The search for biomarkers of neurodegenerative diseases via fMRI functional connectivity (FC) research has yielded inconsistent results. Yet, most FC studies are blind to non-linear brain dynamics. To circumvent this limitation, we developed a “weighted Symbolic Dependence Metric” (wSDM) measure. Using symbolic transforms, we factor in local and global temporal features of the BOLD signal to weigh a robust copula-based dependence measure by symbolic similarity, capturing both linear and non-linear associations. We compared this measure with a linear connectivity metric (Pearson’s R) in its capacity to identify patients with behavioral variant frontotemporal dementia (bvFTD) and controls based on resting-state data. We recruited participants from two international centers with different MRI recordings to assess the consistency of our measure across heterogeneous conditions. First, a seed-analysis comparison of the salience network (a specific target of bvFTD) and the default-mode network (as a complementary control) between patients and controls showed that wSDM yields better identification of resting-state networks. Moreover, machine learning analysis revealed that wSDM yielded higher classification accuracy. These results were consistent across centers, highlighting their robustness despite heterogeneous conditions. Our findings underscore the potential of wSDM to assess fMRI-derived FC data, and to identify sensitive biomarkers in bvFTD.
Link to the resource
https://www.nature.com/articles/s41598-018-29538-9#Abs1Source
Scientific Reports; Vol. 8 (2018)
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