Brain Network Organization and Social Executive Performance in Frontotemporal Dementia

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Date
2016-02Authors
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de EnvejecimientoSedeño, Lucas
Couto, Blas
García Cordero, Indira
Melloni, Margherita
Baez, Sandra
Morales Sepúlveda, Juan Pablo
Fraiman, Daniel
Huepe, David
Hurtado, Esteban
Matallana Eslava, Diana
Kuljis, Rodrigo
Torralva, Teresa
Chialvo, Dante
Sigman, Mariano
Piguet, Olivier
Manes, Facundo
Ibanez, Agustin
Type
Artículo de revista
ISSN
1355-6177 / 1469-7661 (Electrónico)
Pages
250-262
Tipo
Artículo de revistaShare this record
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English Title
Brain Network Organization and Social Executive Performance in Frontotemporal DementiaAbstract
Objectives: Behavioral variant frontotemporal dementia (bvFTD) is characterized by early atrophy in the frontotemporoinsular regions. These regions overlap with networks that are engaged in social cognition-executive functions, two hallmarks
deficits of bvFTD. We examine (i) whether Network Centrality (a graph theory metric that measures how important a node is
in a brain network) in the frontotemporoinsular network is disrupted in bvFTD, and (ii) the level of involvement of this
network in social-executive performance. Methods: Patients with probable bvFTD, healthy controls, and frontoinsular stroke
patients underwent functional MRI resting-state recordings and completed social-executive behavioral measures. Results:
Relative to the controls and the stroke group, the bvFTD patients presented decreased Network Centrality. In addition, this
measure was associated with social cognition and executive functions. To test the specificity of these results for the Network
Centrality of the frontotemporoinsular network, we assessed the main areas from six resting-state networks. No group differences or behavioral associations were found in these networks. Finally, Network Centrality and behavior distinguished bvFTD
patients from the other groups with a high classification rate. Conclusions: bvFTD selectively affects Network Centrality in
the frontotemporoinsular network, which is associated with high-level social and executive profile.
Keywords
Functional connectivityGraph theory analysis
Frontoinsular stroke
Neurodegenerative disease
fMRI resting-state
Node centrality
Source
Journal of the International Neuropsychological Society; Vol. 22 Núm. 2 (2016)
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