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dc.rights.licenceAttribution-NonCommercial 4.0 International*
dc.contributor.authorPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
dc.contributor.authorSantamaría García, Hernando
dc.contributor.authorReyes Gavilán, Pablo Alexander
dc.contributor.authorGarcía, Adolfo
dc.contributor.authorBáez Buitrago, Sandra Jimena
dc.contributor.authorMartínez, Ángela
dc.contributor.authorSantacruz, José Manuel
dc.contributor.authorSlachevsky Chonchol, Andrea María
dc.contributor.authorSigman, Mariano
dc.contributor.authorMatallana Eslava, Diana Lucía
dc.contributor.authorIbañez, Agustín
dc.sourceJournal of Alzheimer's Disease; Vol. 54 (2016)spa
dc.titleFirst symptoms and neurocognitive correlates of behavioral variant frontotemporal dementiaspa
dc.title.englishFirst symptoms and neurocognitive correlates of behavioral variant frontotemporal dementiaspa
dc.description.tipoarticuloArtículo originalspa
dc.format.soportePapel / Electrónicospa
dc.subject.keywordBehavioral variant frontotemporal dementiaspa
dc.subject.keywordFirst symptomspa
dc.subject.keywordVoxel-based morphometryspa
dc.description.abstractenglishBackground: Previous works highlight the neurocognitive differences between apathetic and disinhibited clinical presentations of the behavioral variant frontotemporal dementia (bvFTD).However, little is knownregarding howthe early presentation (i.e., first symptom) is associated to the neurocognitive correlates of the disease’s clinical presentation at future stages of disease. Objectives: We analyzed the neurocognitive correlates of patients with bvFTD who debuted with apathy or disinhibition as first symptom of disease. Methods: We evaluated the neuropsychological, clinical, and neuroanatomical (3T structural images) correlates in a group of healthy controls (n = 30) and two groups of bvFTD patients (presented with apathy [AbvFTD, n = 18] or disinhibition [DbvFTD, n = 16]). To differentiate groups according to first symptoms, we used multivariate analyses. Results: The first symptom in patients described the evolution of the disease. AbvFTD and DbvFTD patients showed increased brain atrophy and increased levels of disinhibition and apathy, respectively. Whole brain analyzes in AbvFTD revealed atrophy in the frontal, insular, and temporal areas. DbvFTD, in turn, presented atrophy in the prefrontal regions, temporoparietal junction, insula, and temporoparietal region. Increased atrophy in DbvFTD patients (compared to AbvFTD) was observed in frontotemporal regions. Multivariate analyses confirmed that a set of brain areas including right orbitofrontal, right dorsolateral prefrontal, and left caudate were enough to distinguish the patients’ subgroups. Conclusion: First symptom in bvFTD patients described the neurocognitive impairments after around three years of disease, playing an important role in the early detection, disease tracking, and neuroanatomical specification of bvFTD, as well as in future research on potential disease-modifying
dc.type.localArtículo de revistaspa

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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International