Impact of sensor-augmented pump therapy with predictive low-glucose management on hypoglycemia and glycemic control in patients with type 1 diabetes mellitus : 1-year follow-up
AuthorsPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística
Gómez, Ana María
Henao, Diana C.
Rondón, Martín A.
García Jaramillo, María A.
León Vargas, Fabián
Taboada, Lucía B.
Artículo de revista
18780334 / 18714021 (Electrónico)
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AIMS: To describe real-life experience with sensor-augmented pump therapy with predictive low-glucose management (SAPT-PLGM), in terms of hypoglycemia and glycemic control after one year of follow-up in T1D patients with hypoglycemia as the main indication of therapy. METHODS: Retrospective cohort study under real life conditions. Baseline and one-year follow-up variables of glycemic control, hypoglycemia and glycemic variability were compared. RESULTS: Fifty patients were included, 31 on prior treatment with SAPT with low-glucose suspend (LGS) feature and 19 on multiple dose insulin injections (MDI). Mean HbA1c decreased in the MDI group (8.24%-7.08%; p = 0.0001). HbA1c change was not significant in the SAPT-LGS group. Area under the curve (AUC) below 70 mg/dl improved in both SAPT-LGS and MDI groups while AUC, %time and events below 54 mg/dl decreased in SAPT-LGS group. Glycemic variability improved in the MDI group. Less patients presented severe hypoglycemia with SAPT-PLGM in both groups, however the change was non-significant. CONCLUSIONS: Under real life conditions, SAPT-PLGM reduced metrics of hypoglycemia in patients previously treaded with MDI and SAPT-LGS without deteriorating glycemic control in SAPT-LGS patients, while improving it in patients treated with MDI.
Magazine magazine magazine in ScopusQ2
Glycated hemoglobin A
Insulin infusion systems
Sensor-augmented pump therapy
Link to the resourcehttps://eds-a-ebscohost-com.ezproxy.javeriana.edu.co/eds/detail/detail?vid=1&sid=3eb45100-1e58-438f-83f2-c9564389522e%40sessionmgr4007&bdata=Jmxhbmc9ZXMmc2l0ZT1lZHMtbGl2ZQ%3d%3d#AN=edselc.2-52.0-85068894227&db=edselc
SourceDiabetes and Metabolic Syndrome: Clinical Research and Reviews; Vol. 13 Núm. 4 (2019)
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