Prevalence of chagas disease in Colombia : a systematic review and meta-analysis
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Datum
2019-01-07Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística
Typ
Artículo de revista
ISSN
1932-6203 (Electrónico)
Seiten
1-18
Artikeltyp
Artículo de investigación
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Background
Despite the adoption of campaigns to interrupt the main vector and to detect Trypanosoma
cruzi in blood banks, millions of people are still chronically infected; however, the prevalence
data are limited, and the epidemiology of Chagas disease has not been systematically evaluated. This study aimed to estimate the prevalence of Chagas disease in Colombia.
Methods
A systematic literature review and meta-analysis was conducted to select all observational
studies reporting the prevalence of Chagas disease in Colombia, based on serological diagnosis in participants of any age and published between January 2007 and November 2017.
Pooled estimates and 95% confidence intervals (95% CIs) were calculated using randomeffects models. In addition, the I
2 statistic was calculated.
Results
The literature search yielded a total of 1,510 studies; sixteen articles with relevant prevalence
data were included in the systematic review. Of these, only 12 articles were included for entry
in the meta-analysis. The pooled prevalence of Chagas disease across studies was 2.0%
(95% CI: 1.0–4.0). A high degree of heterogeneity was found among studies (I2 > 75%; p <
0.001). The publication bias was not statistically significant (Egger’s test, p = 0.078). The
highest pooled prevalences were found in the adult population (3.0%, 95% CI: 1.0–4.0), pregnant women (3.0%, 95% CI: 3.0–4.0) and the Orinoco region (7.0%, 95% CI: 2.2–12.6).
Conclusions
The results indicate that the T. cruzi-infected population is aging, the adult population, pregnant women and that the Orinoco region (department of Casanare) have the highest prevalences. These results highlight the need to maintain screening and surveillance programs to
identify people with chronic T. cruzi infections.
Räumliche Abdeckung
ColombiaVerknüpfen Sie mit der Ressource
https://www.ncbi.nlm.nih.gov/pubmed/30615644Herkunft
PLoS One; Vol. 14 Núm. 1 (2019)
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