Smokers with normal spirometry: impact of computed tomography–detected emphysema, functional mechanisms of dyspnea, and clinical significance of symptoms
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Fecha
2018-08-22Autor(es)
Tobón Trujillo, ManuelaGil-Torres, Pablo Ramón
Torres-González, July
Canas, Alejandra
Celis-Preciado, Carlos Andrés
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Grupo de Investigación de Enfermedades Crónicas del Adulto
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumología
Tipo
Artículo de revista
ISSN
1073-449X / 1535-4970 (Electrónico)
Páginas
1085–1087
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Abstract
Individuals with a history of smoking, chronic respiratory symptoms, and normal spirometry represent a group of particular interest as they have distinctive clinical and radiographic characteristics and have increased risk of adverse outcomes. Three recent studies have reported the mechanisms of dyspnea, the importance of the presence of symptoms in relation to clinical outcomes, and the impact of the presence of emphysema on low-dose chest computed tomography (CT) in this group of patients; these data have contributed to better comprehension of this clinically significant entity. Chest (1) Reviewed by Manuela Tobon-Trujillo Chronic bronchitis and emphysema have been shown to make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD), and their assessment by CT scan provides objective measures that correlate well with histopathologic findings, degree of expiratory airflow obstruction, and more rapid disease progression (2-4). Alcaide and colleagues published a cross-sectional study with data on 203 current/former smokers with normal spirometry: 154 with emphysema visually detected by CT and 49 without emphysema, all part of a lung cancer screening program; clinical and lung function were obtained at the same time as low-dose chest CT.
Enlace al recurso
http://www.atsjournals.org/doi/pdf/10.1164/rccm.201711-2256RRFuente
American Journal of Respiratory and Critical Care Medicine; Volumen 198 Número 8 (2018)
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