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dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.contributor.authorGarcía Acero, Mary Alexandra
dc.contributor.authorMoreno Niño, Olga Maria
dc.contributor.authorSuarez Obando, Fernando
dc.contributor.authorRojas Moreno, Adriana Patricia
dc.identifier.issn1661-7649 / 1661-7657 (Electrónico)spa
dc.sourceCurrent Urology; Vol. 13 Núm. 4 (2020)spa
dc.titleDisorders of sexual development : current status and progress in the diagnostic approachspa
dc.description.tipoarticuloArtículo de revisiónspa
dc.format.soportePapel / Electrónicospa
dc.subject.keywordGenetic pathwayspa
dc.subject.keywordGónada bipotencialspa
dc.subject.keywordSex differencesspa
dc.subject.keywordDisorders of sexual developmentspa
dc.subject.keywordDifferential developmentspa
dc.description.abstractenglishDisorders of sexual development (DSD) are conditions with an atypical chromosomal, gonadal or phenotypic sex, which leads to differences in the development of the urogenital tract and different clinical phenotypes. Some genes have been implicated in the sex development during gonadal and functional differentiation where the maintenance of the somatic sex of the gonad as either male or female is achieved by suppression of the alternate route. The diagnosis of DSD requires a structured approach, involving a multidisciplinary team and different molecular techniques. We discuss the dimorphic genes and the specific pathways involved in gonadal differentiation, as well as new techniques for genetic analysis and their diagnostic value including epigenetic mechanisms, expanding the evidence in the diagnostic approach of individuals with DSD to increase knowledge of the
dc.type.localArtículo de revistaspa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana

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Atribución-NoComercial 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución-NoComercial 4.0 Internacional