Disorders of sexual development : current status and progress in the diagnostic approach

Garcia-Acero, Mary; Moreno Niño, Olga María; Suárez-Obando, F.; Rojas, Adriana

dc.rights.licence	Atribución-NoComercial 4.0 Internacional	*
dc.contributor.author	Garcia-Acero, Mary
dc.contributor.author	Moreno Niño, Olga María
dc.contributor.author	Suárez-Obando, F.
dc.contributor.author	Rojas, Adriana
dc.date.accessioned	2020-10-11T16:24:59Z
dc.date.available	2020-10-11T16:24:59Z
dc.date.created	2020-01-07
dc.identifier	https://www.karger.com/Article/FullText/499274	spa
dc.identifier.issn	1661-7649 / 1661-7657 (Electrónico)	spa
dc.identifier.uri	http://hdl.handle.net/10554/51331
dc.format	PDF	spa
dc.format.mimetype	application/pdf	spa
dc.language	Inglés	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	*
dc.source	Current Urology; Volumen 13 Número 4 (2020)	spa
dc.title	Disorders of sexual development : current status and progress in the diagnostic approach	spa
dc.type	info:eu-repo/semantics/article
dc.type.hasversion	http://purl.org/coar/version/c_ab4af688f83e57aa
dc.description.quartilescopus	Q3	spa
dc.identifier.doi	https://doi.org/10.1159/000499274	spa
dc.description.tipoarticulo	Artículo de revisión	spa
dc.description.paginas	169-178	spa
dc.description.comunidad	Pacientes con Trastornos del desarrollo sexual
dc.format.soporte	Papel / Electrónico	spa
dc.subject.keyword	Genetic pathway	spa
dc.subject.keyword	Gónada bipotencial	spa
dc.subject.keyword	Sex differences	spa
dc.subject.keyword	Disorders of sexual development	spa
dc.subject.keyword	Differential development	spa
dc.description.abstractenglish	Disorders of sexual development (DSD) are conditions with an atypical chromosomal, gonadal or phenotypic sex, which leads to differences in the development of the urogenital tract and different clinical phenotypes. Some genes have been implicated in the sex development during gonadal and functional differentiation where the maintenance of the somatic sex of the gonad as either male or female is achieved by suppression of the alternate route. The diagnosis of DSD requires a structured approach, involving a multidisciplinary team and different molecular techniques. We discuss the dimorphic genes and the specific pathways involved in gonadal differentiation, as well as new techniques for genetic analysis and their diagnostic value including epigenetic mechanisms, expanding the evidence in the diagnostic approach of individuals with DSD to increase knowledge of the etiology.	spa
dc.type.local	Artículo de revista	spa
dc.contributor.corporatename	Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
dc.contributor.javerianateacher	Moreno Niño, Olga María
dc.contributor.javerianateacher	Suárez-Obando, F.
dc.contributor.javerianateacher	Rojas, Adriana
dc.description.indexing	Revista Internacional - Indexada
dc.description.publindex	B