Discordance rates of biopsy techniques among men with prostate cancer that are candidates for active surveillance

Linder, Brian; Frank, Igor; Umbreit, Eric; Shimko, Mark; Fernández Bonilla, Jose Nicolás; Rangel, Laureano; Karnes, Jeffrey

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dc.rights.licence	Atribución-NoComercial 4.0 Internacional	*
dc.contributor.author	Linder, Brian
dc.contributor.author	Frank, Igor
dc.contributor.author	Umbreit, Eric
dc.contributor.author	Shimko, Mark
dc.contributor.author	Fernández Bonilla, Jose Nicolás
dc.contributor.author	Rangel, Laureano
dc.contributor.author	Karnes, Jeffrey
dc.coverage.temporal	2005-2007
dc.date.accessioned	2020-10-21T01:11:56Z
dc.date.available	2020-10-21T01:11:56Z
dc.date.created	2012
dc.identifier	https://www.auajournals.org/doi/10.1016/j.juro.2012.02.2376	spa
dc.identifier.issn	0022-5347 / 1527-3792 (Electrónico)	spa
dc.identifier.uri	http://hdl.handle.net/10554/51454
dc.format	PDF	spa
dc.format.mimetype	application/pdf	spa
dc.language	Inglés	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	*
dc.source	Journal of Urology; Vol. 187 Núm. 4 Supl. (2012)	spa
dc.title	Discordance rates of biopsy techniques among men with prostate cancer that are candidates for active surveillance	spa
dc.type	info:eu-repo/semantics/article
dc.type.hasversion	http://purl.org/coar/version/c_ab4af688f83e57aa
dc.description.quartilewos	Q1	spa
dc.description.quartilescopus	Q1	spa
dc.identifier.doi	https://doi.org/10.1016/j.juro.2012.02.2376	spa
dc.description.paginas	e887-e887	spa
dc.format.soporte	Papel / Electrónico	spa
dc.description.abstractenglish	INTRODUCTION AND OBJECTIVES: With the ongoing stage migration in the diagnosis of prostate cancer, there has been increased interest in management with active surveillance. Our study examines the ability of two prostate biopsy techniques to predict appropriate candidates for active surveillance.METHODS500 consecutive patients, between 2005 and 2007, that underwent trans-rectal ultrasound guided biopsy by either an office biopsy with 12 cores or a saturation biopsy with ≥18 cores, and subsequent radical prostatectomy were identified. Using criteria of: Gleason score ≤6, clinical stage T1 or T2a, Prostate Specific Antigen (PSA) <10 and ≤33% of cores involved, 220 patients were found to be candidates for active surveillance. Pathology results from the prostatectomy specimens were used determine the discordance rate of each biopsy technique.RESULTSOf the 220 candidates for active surveillance, 124 patients underwent an office biopsy with 12 cores, and 96 patients underwent a saturation biopsy. The median number of cores in the saturation biopsy cohort was 27. There was no statistically significant difference between the groups in terms of median age (p=0.18), pre-operative PSA (p=0.48) and clinical stage (p=0.2). At least one previous negative biopsy had been performed on 20 patients (16%) in the office cohort and 43 patients (45%) in the saturation cohort (p= <0.001). In the 12 core biopsy group, 17 patients (14%) were upgraded to Gleason 7 on pathology from the prostatectomy specimen. In the saturation biopsy group, 14 patients (15%) were upgraded to Gleason 7, and 1 patient (1%) was upgraded to Gleason 8. There was no statistically significant difference in the rate of upgrading between the office and saturation biopsy cohorts (p=0.69). In the office biopsy group, 2 patients (1.6%) were upstaged to pT3 disease, compared to 0 patients (0%) in the saturation biopsy group (p=0.58). No statistically significant difference in the estimated tumor volume of the prostatectomy specimen was seen between the cohorts (p=0.47).CONCLUSIONSCandidates for active surveillance can accurately be predicted with 12 core biopsies. In both cohorts, approximately 1 in 6 patients underwent upgrading based on the pathology of the prostatectomy specimen.	spa
dc.type.local	Artículo de revista	spa
dc.contributor.corporatename	Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Cirugía y Especialidades. Urología