Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord

Olaya C, Mercedes; Michael, F; G, Fabian; Silva, J Luis; Garzon, A L; Bernal, J E

dc.rights.licence	Atribución-NoComercial 4.0 Internacional	*
dc.contributor.author	Olaya C, Mercedes
dc.contributor.author	Michael, F
dc.contributor.author	G, Fabian
dc.contributor.author	Silva, J Luis
dc.contributor.author	Garzon, A L
dc.contributor.author	Bernal, J E
dc.date.accessioned	2021-03-23T15:40:03Z
dc.date.available	2021-03-23T15:40:03Z
dc.date.created	2019
dc.identifier	https://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=edselc&AN=edselc.2-52.0-85064122819&lang=es&site=eds-live	spa
dc.identifier.issn	1934-5798	spa
dc.identifier.uri	http://hdl.handle.net/10554/53316
dc.format	PDF	spa
dc.format.mimetype	application/pdf	spa
dc.language.iso	eng	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	*
dc.title	Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord	spa
dc.type.hasversion	http://purl.org/coar/version/c_ab4af688f83e57aa
dc.description.quartilescopus	Q3	spa
dc.identifier.doi	https://doi.org/10.3233/NPM-1795	spa
dc.subject.keyword	Umbilical cord	spa
dc.subject.keyword	VEGF	spa
dc.subject.keyword	Stillbirth	spa
dc.subject.keyword	Umbilical cord length	spa
dc.description.abstractenglish	Introduction: The umbilical cord (UC) is a vital structure; its alterations affect the newborn and neurological impact can be permanent. Paradoxically, factors that determine it remain unknown. We explore the differential VEGF protein expression in the UC's proximal and distal portions in relation to the hypothesis that the UC has differential growth and that VEGF plays a role in it. Methods: An observational analytical study was performed. One UC segment was taken proximal to fetus and another distal; both were randomly processed; VEGF immunohistochemical analysis was performed; two blinded pathologists read results. Results: Forty-eight newborns were included. Protein expression between the two edges of the umbilical cord, in any kind of cells, was interpreted. Endothelium, amnion, and stromal cells expressed VEGF; the first two were not different between opposite ends. Stromal cells had differential expression: higher in the proximal to the fetus portion. Conclusion: Knowledge of molecular factors is necessary. UC cells widely expressed VEGF, possibly contributing to UC growth. Even though stromal cell expression was different, the interaction with activity close to the fetus must be explored.	spa
dc.type.local	Artículo de revista	spa
dc.contributor.corporatename	Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
dc.contributor.corporatename	Research Seedbed in Perinatal Medicine Pontificia Universidad Javeriana
dc.identifier.instname	instname:Pontificia Universidad Javeriana	spa
dc.identifier.reponame	reponame:Repositorio Institucional - Pontificia Universidad Javeriana	spa
dc.identifier.repourl	repourl:https://repository.javeriana.edu.co	spa
dc.type.coar	http://purl.org/coar/resource_type/c_6501	spa
dc.description.orcid	https://orcid.org/0000-0002-7147-425X	spa
dc.relation.citationstartpage	47	spa
dc.relation.citationendpage	56	spa
dc.relation.ispartofjournal	Journal of Neonatal-Perinatal Medicine	spa
dc.description.indexing	N/A	spa
dc.relation.citationvolume	12	spa
dc.relation.citationissue	1	spa
dc.rights.coar	http://purl.org/coar/access_right/c_abf2	spa