Glucose levels as a mediator of the detrimental effect of abdominal obesity on relative handgrip strength in older adults

Pérez-Sousa, Miguel Ángel; del Pozo-Cruz, Jesús; Cano Gutiérrez, Carlos Alberto; Ferrebuz, Atilio J.; Sandoval-Cuellar, Carolina; Izquierdo, Mikel; Hernández-Quiñonez, Paula A.; Ramírez-Vélez, Robinson

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dc.rights.licence	Atribución-NoComercial 4.0 Internacional	*
dc.contributor.author	Pérez-Sousa, Miguel Ángel
dc.contributor.author	del Pozo-Cruz, Jesús
dc.contributor.author	Cano Gutiérrez, Carlos Alberto
dc.contributor.author	Ferrebuz, Atilio J.
dc.contributor.author	Sandoval-Cuellar, Carolina
dc.contributor.author	Izquierdo, Mikel
dc.contributor.author	Hernández-Quiñonez, Paula A.
dc.contributor.author	Ramírez-Vélez, Robinson
dc.date.accessioned	2021-04-15T21:35:32Z
dc.date.available	2021-04-15T21:35:32Z
dc.date.created	2020-07-22
dc.identifier	https://www.mdpi.com/2077-0383/9/8/2323	spa
dc.identifier.issn	2077-0383	spa
dc.identifier.uri	http://hdl.handle.net/10554/53573
dc.format	PDF	spa
dc.format.mimetype	application/pdf	spa
dc.language.iso	eng	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	*
dc.title	Glucose levels as a mediator of the detrimental effect of abdominal obesity on relative handgrip strength in older adults	spa
dc.type.hasversion	http://purl.org/coar/version/c_ab4af688f83e57aa
dc.description.quartilewos	Q1	spa
dc.identifier.doi	https://doi.org/10.3390/jcm9082323	spa
dc.subject.keyword	Fat mass	spa
dc.subject.keyword	Obesity	spa
dc.subject.keyword	Muscle strength	spa
dc.subject.keyword	Physical function	spa
dc.subject.keyword	Diabetes	spa
dc.description.abstractenglish	Excess central adiposity accelerates the decline of muscle strength in older people. Additionally, hyperglycemia, independent of associated comorbidities, is related to the loss of muscle mass and strength, and contributes to functional impairment in older adults. We studied the mediation effect of glucose levels, in the relationship between abdominal obesity and relative handgrip strength (HGS). A total of 1571 participants (60.0% women, mean age 69.1 ± 7.0 years) from 86 municipalities were selected following a multistage area probability sampling design. Measurements included demographic and anthropometric/adiposity markers (weight, height, body mass index, and waist circumference). HGS was measured using a digital dynamometer for three sets and the mean value was recorded. The values were normalized to body weight (relative HGS). Fasting glucose was analyzed by enzymatic colorimetric methods. Mediation analyses were performed to identify associations between the independent variable (abdominal obesity) and outcomes (relative HGS), as well as to determine whether fasting glucose levels mediated the relationship between excess adiposity and relative HGS. A total of 1239 (78.8%) had abdominal obesity. Abdominal obesity had a negative effect on fasting glucose (β = 9.04, 95%CI = 5.87 to 12.21); while fasting glucose to relative HGS was inversely related (β = −0.003, 95%CI = −0.005 to −0.001), p < 0.001. The direct effect of abdominal obesity on relative HGS was statistically significant (β = −0.069, 95%CI = −0.082 to −0.057), p < 0.001. Lastly, fasting glucose levels mediates the detrimental effect of abdominal obesity on relative HGS (indirect effect β = −0.002, 95%CI = −0.004 to −0.001), p < 0.001. Our results suggest that the glucose level could worsen the association between abdominal obesity status and lower HGS. Thus, it is plausible to consider fasting glucose levels when assessing older adults with excess adiposity and/or suspected loss of muscle mass.	spa
dc.type.local	Artículo de revista	spa
dc.contributor.corporatename	Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
dc.identifier.instname	instname:Pontificia Universidad Javeriana	spa
dc.identifier.reponame	reponame:Repositorio Institucional - Pontificia Universidad Javeriana	spa
dc.identifier.repourl	repourl:https://repository.javeriana.edu.co	spa
dc.type.coar	http://purl.org/coar/resource_type/c_beb9	spa
dc.description.orcid	https://orcid.org/0000-0001-5680-7880	spa
dc.relation.citationstartpage	3	spa
dc.relation.citationendpage	12	spa
dc.relation.ispartofjournal	Journal of Clinical Medicine	spa
dc.contributor.javerianateacher	Cano Gutiérrez, Carlos Alberto
dc.description.indexing	Revista Internacional - Indexada	spa
dc.relation.citationvolume	9	spa
dc.relation.citationissue	8	spa
dc.rights.coar	http://purl.org/coar/access_right/c_abf2	spa