Hippocampal subfields and decline in activities of daily living in Alzheimer’s disease and dementia with Lewy bodies
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Fecha
2020-09-24Autor(es)
Borda, Miguel GermánJaramillo-Jimenez, Alberto
Tovar-Rios, Diego A
Ferreira, Daniel
Garcia-Cifuentes, Elkin
Vik-Mo, Audun Osland
Aarsland, Vera
Aarsland, Dag
Oppedal, Ketil
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
Tipo
Artículo de revista
ISSN
1758-2024 / 1758-2032 (Electrónico)
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Abstract
Background: Hippocampal atrophy is presented in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline. Materials & methods: 12 HSv were computed from structural magnetic resonance images using Freesurfer 6.0 segmentation. Functional decline was assessed using the rapid disability rating scale score. Linear regressions were conducted. Results: In AD, HSv were smaller bilaterally. However, HSv were not associated with functional decline. Conclusion: Functional decline does not depend on HSv in mild AD and DLB.
Keywords
Activities of daily livingAlzheimer’s disease
Dementia with Lewy bodies
Functional decline
Hippocampal subfields
Enlace al recurso
https://www.futuremedicine.com/doi/pdf/10.2217/nmt-2020-0039Fuente
Neurodegenerative Disease Management; Volumen 10 Número 6 , Páginas 357 - 367 (2020)
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