Hippocampal subfields and decline in activities of daily living in Alzheimer’s disease and dementia with Lewy bodies
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Date
2020-09-24Les auteurs
Borda, Miguel GermánJaramillo-Jimenez, Alberto
Tovar-Rios, Diego A
Ferreira, Daniel
Garcia-Cifuentes, Elkin
Vik-Mo, Audun Osland
Aarsland, Vera
Aarsland, Dag
Oppedal, Ketil
Auteur(s) d'entreprise
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
Type
Artículo de revista
ISSN
1758-2024 / 1758-2032 (Electrónico)
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Abstrait
Background: Hippocampal atrophy is presented in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline. Materials & methods: 12 HSv were computed from structural magnetic resonance images using Freesurfer 6.0 segmentation. Functional decline was assessed using the rapid disability rating scale score. Linear regressions were conducted. Results: In AD, HSv were smaller bilaterally. However, HSv were not associated with functional decline. Conclusion: Functional decline does not depend on HSv in mild AD and DLB.
Keywords
Activities of daily livingAlzheimer’s disease
Dementia with Lewy bodies
Functional decline
Hippocampal subfields
Lien vers la ressource
https://www.futuremedicine.com/doi/pdf/10.2217/nmt-2020-0039Origine
Neurodegenerative Disease Management; Volumen 10 Número 6 , Páginas 357 - 367 (2020)
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