Tongue muscle mass is associated with total grey matter and hippocampal volumes in Dementia with Lewy Bodies
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Date
2022-02-01Authors
Borda, Miguel GermánCastellanos-Perilla, Nicolás
Tovar Rios, Diego Alejandro
Ferreira, Daniel
Duque, Gustavo
Aarsland, Dag
Corporate Author(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
Type
Artículo de revista
ISSN
0167-4943 / 1872-6976 (Electrónico)
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Abstract
Background:
Age-related neurodegeneration, sarcopenia, and ectopic fat accumulation are conditions with shared pathways that remain poorly understood. We have measured muscle volume and fat accumulation in masseter and tongue muscle, and aim to explore their association with the total grey matter volume using MRI in older adults recently diagnosed with Alzheimer's disease (AD) and Dementia with Lewy bodies (DLB).
Methods:
In this cross-sectional study, people newly diagnosed with mild AD (n=33) and DLB (n=20) underwent structural head MRI. Muscle volume and intramuscular fat (iMAT) of the tongue and masseter were computed using Slice-O-Matic software for segmentation. Total grey volume and hippocampal volumetric segmentation were performed with the FreeSurfer image analysis suite version 6.0. Independent regression models were employed to analyse the associations.
Results:
Tongue iMAT was higher and total grey volume lower in DLB compared to AD. In the DLB group, tongue muscle was positively associated with total grey matter volume Est 0.92 (SE 0.24 p-value 0.002), left- Est 0.01 (SE 0.0028 p-value 0,002), and right- Est 0.0088 (SE 0.0027 p-value: 0.005) hippocampal volume. There were no statistically significant results for AD.
Conclusion:
Tongue muscle volume was positively associated with hippocampal and total grey volume in DLB. Longitudinal designs are required to explore the extent and significance of this association.
Keywords
DemenciaGrasa intramuscular
Músculo
Demencia con cuerpos de Lewy
Enfermedad de Alzheimer
Sarcopenia
Spatial coverage
NoruegaLink to the resource
https://www.sciencedirect.com/science/article/pii/S0167494322000280?via%3DihubSource
Archives of Gerontology and Geriatrics; Volumen 100 , Páginas 1 - 6 (2022)
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