Assessment of placental extracellular vesicles-associated fas ligand and TNF-related apoptosis-inducing ligand in pregnancies complicated by early and late onset preeclampsia
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2021-07-23Autor(es)
Ayala Ramírez, PaolaMachuca-Acevedo, Catalina
Gámez, Tatiana
Quijano Gómez, Sandra Milena
Barreto Prieto, Alfonso
Silva Herrera, Jaime Luis
Olaya Contreras, Mercedes
García-Robles, Reggie
Rivatrem
Autor(es) Corporativo(s)
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
Pontificia Universidad Javeriana. Facultad de Medicina. Hospital Universitario San Ignacio
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
Tipo
Artículo de revista
ISSN
1664-042X
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Resumo
Preeclampsia (PE) is a hypertensive disorder that affects 2–8% of pregnancies and is one
of the main causes of fetal, neonatal, and maternal mortality and morbidity worldwide.
Although PE etiology and pathophysiology remain unknown, there is evidence that the
hyperactivation of maternal immunity cells against placental cells triggers trophoblast
cell apoptosis and death. It has also been reported that placenta-derived extracellular
vesicles (EV) carry Fas ligand (FasL) and Tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and trigger apoptosis in Jurkat T cells. This study aimed
to quantify and compare FasL and TRAIL expression in EV derived from cultures
of placenta explants from women with PE (early versus late) and women with
uncomplicated pregnancies. Also, the study assessed EV capacity to induce apoptosis
in Jurkat T cells. The authors isolated EV from placenta explant cultures, quantified
FasL and TRAIL using ELISA, and analyzed EV apoptosis-inducing capability by flow
cytometry. Results showed increased FasL and TRAIL in EV derived from placenta
of women with PE, and increased EV apoptosis-inducing capability in Jurkat T cells.
These results offer supporting evidence that EV FasL and TRAIL play a role in the
pathophysiology of PE.
Palavras chave
PregnancyHypertension Disorder Complicating Pregnancy
Exosome (Vesicle)
Apoptosis
Placental Culture
Cobertura espacial (cidades)
Bogotá (Colombia)Cobertura Espacial
ColombiaCobertura temporária
2018Comunidade
Mujeres embarazadasLink para o recurso
https://www.frontiersin.org/articles/10.3389/fphys.2021.708824/fullFonte
Frontiers in Physiology; Volumen 12 , Páginas 1 - 8 (2021)
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