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Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis

dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.contributor.authorSoto-Chávez, Maria Juliana
dc.contributor.authorMuñoz, Óscar
dc.contributor.authorAlzate-Granados, Juan Pablo
dc.contributor.authorLombo, Carlos
dc.contributor.authorHenao-Carrillo, Diana Cristina
dc.contributor.authorGomez-Medina, Ana Maria
dc.coverage.temporal2022
dc.date.accessioned2023-03-14T12:18:02Z
dc.date.available2023-03-14T12:18:02Z
dc.date.created2022-08-02
dc.identifierhttps://www.diabetesresearchclinicalpractice.com/article/S0168-8227(22)00833-6/fulltextspa
dc.identifier.issn0168-8227 / 1872-8227 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/63725
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleEffectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysisspa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.description.quartilewosQ1spa
dc.description.quartilescopusQ1spa
dc.identifier.doihttps://doi.org/10.1016/j.diabres.2022.110019spa
dc.subject.keywordType 2 diabetesspa
dc.subject.keywordInpatient managementspa
dc.subject.keywordDPP4 inhibitorsspa
dc.subject.keywordGLP-1 receptor agonistspa
dc.subject.keywordHypoglycemiaspa
dc.description.abstractenglishBackground: Current guidelines recommend insulin alone for in-hospital management of diabetes, but growing information suggests that new oral or injectable agents may be as effective and safe. Methods: Systematic review and meta-analysis with evidence from randomized (RCT) and non-randomized (NRS) studies in PubMed, EMBASE and LILACS databases up to February 10, 2022, for studies including hospitalized type 2 diabetes patients, comparing dipeptidyl peptidase 4 inhibitors (DPP4i), sodium glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP1Ra) with insulin alone for glycemic control and safety outcomes. Findings: 7 RCT and 3 NRTs were included. There were no differences in mean blood glucose, measurements within range or rate of hypoglycemia between DPP4i and insulin. We found a lower mean glucose for GLP1Ra plus insulin subgroup (−16.36 mg/dL, 95 % CI −27.31, −5.41; I2 = 0 %) with lower incidence of hypoglycemia < 70 mg/dL with GLP1Ra (RR 0.31, CI 95 % 0.14–0.70, I2 = 0 %). SGLT2i data was limited. Adverse events rates were similar between treatments. Conclusion: Our review suggests that inpatient management in the general ward with DPP4i and GLP1Ra is as effective and safe as management with insulin. More randomized studies are required to support these findings before they could be recommended as usual practice.spa
dc.type.localArtículo de revistaspa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Endocrinologíaspa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Medicina Interna
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.type.coarhttp://purl.org/coar/resource_type/c_dcae04bcspa
dc.description.orcidhttps://orcid.org/0000-0003-4946-8774spa
dc.description.orcidhttps://orcid.org/0000-0001-5401-0018spa
dc.description.orcidhttps://orcid.org/0000-0001-8344-494Xspa
dc.description.orcidhttps://orcid.org/0000-0002-6392-7554spa
dc.description.orcidhttps://orcid.org/0000-0002-1353-148Xspa
dc.description.orcidhttps://orcid.org/0000-0002-8907-3470spa
dc.relation.citationstartpage1spa
dc.relation.citationendpage11spa
dc.relation.ispartofjournalDiabetes Research and Clinical Practicespa
dc.contributor.javerianateacherMuñoz, Óscar
dc.contributor.javerianateacherAlzate-Granados, Juan Pablo
dc.contributor.javerianateacherHenao-Carrillo, Diana Cristina
dc.contributor.javerianateacherGomez-Medina, Ana Maria
dc.description.indexingRevista Internacional - Indexadaspa
dc.relation.citationvolume191spa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.description.publindexA1spa
dc.description.esciNospa


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