Low-density lipoprotein cholesterol goal achievement in patients with familial hypercholesterolemia in countries outside Western Europe : the international cholesterol management practice study
| dc.contributor.author | Blom, Dirk J. | |
| dc.contributor.author | Almahmeed, Wael A. | |
| dc.contributor.author | Al-Rasadi, Khalid H. | |
| dc.contributor.author | Azuri, Joseph | |
| dc.contributor.author | Daclin, Véronique | |
| dc.contributor.author | Kayıkçıoğlu, Meral | |
| dc.contributor.author | Mercier, Florence | |
| dc.contributor.author | Ruiz J, Alvaro | |
| dc.contributor.author | Santos, Raúl | |
| dc.contributor.corporatename | Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística | |
| dc.date.accessioned | 2020-03-19T11:41:19Z | |
| dc.date.accessioned | 2020-04-15T13:25:15Z | |
| dc.date.available | 2020-03-19T11:41:19Z | |
| dc.date.available | 2020-04-15T13:25:15Z | |
| dc.date.created | 2019-05-07 | |
| dc.description.abstractenglish | BACKGROUND: The cross-sectional observational International ChoLesterol management Practice Study study assessed achievement of European Society of Cardiology/European Atherosclerosis Society low-density lipoprotein cholesterol (LDL-C) targets in patients outside Western Europe. OBJECTIVE: The aim of the study was to assess LDL-C goal achievement in International ChoLesterol management Practice Study participants with familial hypercholesterolemia (FH). METHODS: A total of 334 patients (aged ≥18 years) with definite or probable FH (Dutch Lipid Clinic Network score ≥6; 43.1% genetically confirmed) who had been receiving stable lipid-modifying therapy (LMT) for ≥3 months were enrolled. RESULTS: The mean ± standard deviation age of the patients was 58.5 ± 13.1 years, 49.1% were male, and 48.2% had coronary artery disease. Most were receiving statin (∼99%). Of these, 57.6% were on high-intensity statin therapy, 49.1% on the highest dose available, and 13.0% used a statin together with a cholesterol absorption inhibitor (CAI). Mean ± standard deviation LDL-C level was 5.6 ± 3.0 mmol/L before LMT and 3.3 ± 2.0 mmol/L at enrollment. Overall, 32.0% of patients achieved their LDL-C target. Target achievement rates were 36.6% for patients with coronary artery disease, and 27.5% for those without, and 27.9%, 28.0%, and 37.5% for patients treated with a statin plus CAI, highest-dose statin (no CAI), and lower-dose statin (no CAI), respectively. CONCLUSIONS: LDL-C target achievement rates were low in patients with FH, even in those receiving intensive LMT. Factors that are likely to have contributed to the low LDL-C target achievement rates include high baseline LDL-C, inadequate statin dosages, and low use of CAI. Many patients would have been eligible for proprotein convertase subtilisin/kexin type 9 inhibitor therapy. | spa |
| dc.description.comunidad | Pacientes | spa |
| dc.description.paginas | 594-600 | spa |
| dc.description.quartilescopus | Q1 | spa |
| dc.description.quartilewos | Q2 | spa |
| dc.format | spa | |
| dc.format.mimetype | application/pdf | spa |
| dc.format.soporte | Papel / Electrónico | spa |
| dc.identifier | https://www.lipidjournal.com/article/S1933-2874(19)30179-5/fulltext | spa |
| dc.identifier.doi | https://doi.org/10.1016/j.jacl.2019.05.004 | spa |
| dc.identifier.issn | 1933-2874 | spa |
| dc.identifier.uri | http://hdl.handle.net/10554/47721 | |
| dc.language | spa | spa |
| dc.rights.licence | Atribución-NoComercial 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.source | Journal of Clinical Lipidology; Vol. 13 Núm. 4 (2019) | spa |
| dc.subject.keyword | Hyperlipoproteinemia type II | spa |
| dc.subject.keyword | Statins | spa |
| dc.subject.keyword | Cholesterol | spa |
| dc.subject.keyword | Observational study | spa |
| dc.subject.keyword | Guidelines | spa |
| dc.title | Low-density lipoprotein cholesterol goal achievement in patients with familial hypercholesterolemia in countries outside Western Europe : the international cholesterol management practice study | spa |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.hasversion | http://purl.org/coar/version/c_ab4af688f83e57aa | |
| dc.type.local | Artículo de revista | spa |