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Systematic reviews experience major limitations in reporting absolute effects

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dc.contributor.authorAlonso-Coello, Pablo
dc.contributor.authorCarrasco-Labra, Alonso
dc.contributor.authorBrignardello-Petersen, Romina
dc.contributor.authorNeumann, Ignacio
dc.contributor.authorAkl, Elie A.
dc.contributor.authorVernooij, Robin W. M.
dc.contributor.authorJohnston, Brad C.
dc.contributor.authorSun, Xin
dc.contributor.authorBriel, Matthias
dc.contributor.authorBusse, Jason W.
dc.contributor.authorEbrahim, Shanil
dc.contributor.authorGranados, Carlos E.
dc.contributor.authorIorio, Alfonso
dc.contributor.authorIrfan, Affan
dc.contributor.authorMartínez García, Laura
dc.contributor.authorMustafa, Reem A.
dc.contributor.authorRamírez-Morera, Anggie
dc.contributor.authorSelva, Anna
dc.contributor.authorSolà, Ivan
dc.contributor.authorSanabria, Andrea Juliana
dc.contributor.authorTikkinen, Kari
dc.contributor.authorVandvik, Per Olav
dc.contributor.authorZazueta, Oscar E.
dc.contributor.authorZhang, Yuqing
dc.contributor.authorZhou, Qi
dc.contributor.authorSchünemann, Holger
dc.contributor.authorGuyatt, Gordon H.
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Radiología e Imágenes Diagnósticas
dc.date.accessioned2020-10-26T18:19:44Z
dc.date.available2020-10-26T18:19:44Z
dc.date.created2016-04-01
dc.description.abstractenglishObjectives: Expressing treatment effects in relative terms yields larger numbers than expressions in absolute terms, affecting the judgment of the clinicians and patients regarding the treatment options. It is uncertain how authors of systematic reviews (SRs) absolute effect estimates are reported in. We therefore undertook a systematic survey to identify and describe the reporting and methods for calculating absolute effect estimates in SRs. Study design and setting: Two reviewers independently screened title, abstract, and full text and extracted data from a sample of Cochrane and non-Cochrane SRs. We used regression analyses to examine the association between study characteristics and the reporting of absolute estimates for the most patient-important outcome. Results: We included 202 SRs (98 Cochrane and 104 non-Cochrane), most of which (92.1%) included standard meta-analyses including relative estimates of effect. Of the 202 SRs, 73 (36.1%) reported absolute effect estimates for the most patient-important outcome. SRs with statistically significant effects were more likely to report absolute estimates (odds ratio, 2.26; 95% confidence interval: 1.08, 4.74). The most commonly reported absolute estimates were: for each intervention, risk of adverse outcomes expressed as a percentage (41.1%); number needed to treat (26.0%); and risk for each intervention expressed as natural units or natural frequencies (24.7%). In 12.3% of the SRs that reported absolute effect estimates for both benefit and harm outcomes, harm outcomes were reported exclusively as absolute estimates. Exclusively reporting of beneficial outcomes as absolute estimates occurred in 6.8% of the SRs. Conclusions: Most SRs do not report absolute effects. Those that do often report them inadequately, thus requiring users of SRs to generate their own estimates of absolute effects. For any apparently effective or harmful intervention, SR authors should report both absolute and relative estimates to optimize the interpretation of their findings. Keywords: Absolute effect estimates; Absolute measures; Decision making; Framing; Reporting; Risk difference; Systematic review.spa
dc.description.paginas16-26spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.description.tipoarticuloArtículo de revisiónspa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://www.jclinepi.com/article/S0895-4356(15)00505-3/fulltext#secsectitle0010spa
dc.identifier.doihttps://doi.org/10.1016/j.jclinepi.2015.11.002spa
dc.identifier.issn0895-4356 / 1878-5921 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/51516
dc.languageEspañolspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceJournal of Clinical Epidemiology; Vol. 72 (2016)spa
dc.subject.keywordAbsolute measuresspa
dc.subject.keywordAbsolute effect estimatesspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordReportingspa
dc.subject.keywordFramingspa
dc.subject.keywordRisk differencespa
dc.subject.keywordDecision makingspa
dc.titleSystematic reviews experience major limitations in reporting absolute effectsspa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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