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Social and non-social working memory in neurodegeneration

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dc.contributor.authorLegaz, Agustina
dc.contributor.authorPrado, Pavel
dc.contributor.authorMoguilner, Sebastian
dc.contributor.authorBaez, Sandra
dc.contributor.authorSantamaria Garcia, Hernando
dc.contributor.authorBirba, Agustina
dc.contributor.authorBarttfeld, Pablo
dc.contributor.authorGarcía, Adolfo M.
dc.contributor.authorFittipaldi, Sol
dc.contributor.authorIbañez, Agustín
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Psiquiatría y Salud Mentalspa
dc.contributor.javerianateacherSantamaria Garcia, Hernando
dc.date.accessioned2023-08-31T15:00:51Z
dc.date.available2023-08-31T15:00:51Z
dc.date.created2023-05-29
dc.description.abstractenglishAlthough social functioning relies on working memory, whether a social-specific mechanism exists remains unclear. This undermines the characterization of neurodegenerative conditions with both working memory and social deficits. We assessed working memory domain-specificity across behavioral, electrophysiological, and neuroimaging dimensions in 245 participants. A novel working memory task involving social and non-social stimuli with three load levels was assessed across controls and different neurodegenerative conditions with recognized impairments in: working memory and social cognition (behavioral-variant frontotemporal dementia); general cognition (Alzheimer’s disease); and unspecific patterns (Parkinson’s disease). We also examined resting-state theta oscillations and functional connectivity correlates of working memory domain-specificity. Results in controls and all groups together evidenced increased working memory demands for social stimuli associated with frontocinguloparietal theta oscillations and salience network connectivity. Canonical frontal theta oscillations and executive-default mode network anticorrelation indexed non-social stimuli. Behavioral-variant frontotemporal dementia presented generalized working memory deficits related to posterior theta oscillations, with social stimuli linked to salience network connectivity. In Alzheimer’s disease, generalized working memory impairments were related to temporoparietal theta oscillations, with non-social stimuli linked to the executive network. Parkinson’s disease showed spared working memory performance and canonical brain correlates. Findings support a social-specific working memory and related disease-selective pathophysiological mechanisms.spa
dc.description.comunidadPacientes con Demencia frontotemporal variante conductualspa
dc.description.comunidadPacientes con enfermedad de Alzheimerspa
dc.description.comunidadPacientes con enfermedad de Parkinsonspa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0001-9422-3579spa
dc.description.publindexA1spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0969996123001869?via%3Dihubspa
dc.identifier.doihttps://doi.org/10.1016/j.nbd.2023.106171spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn0969-9961 / 1095-953X (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/65364
dc.language.isoengspa
dc.relation.citationendpage15spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume183spa
dc.relation.ispartofjournalNeurobiology of Diseasespa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordWorking memoryspa
dc.subject.keywordSocial processingspa
dc.subject.keywordSocial working memoryspa
dc.subject.keywordBehavioral-variant frontotemporal dementiaspa
dc.subject.keywordAlzheimer’s diseasespa
dc.subject.keywordParkinson’s diseasespa
dc.titleSocial and non-social working memory in neurodegenerationspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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