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Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors

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dc.contributor.authorVargas-Espíndola, Luz Alejandra
dc.contributor.authorCuervo-Maldonado, Sonia I.
dc.contributor.authorEnciso-Olivera, José L.
dc.contributor.authorGómez-Rincón, Julio C.
dc.contributor.authorJiménez-Cetina, Leydy
dc.contributor.authorSánchez-Pedraza, Ricardo
dc.contributor.authorGarcía-Guzmán, Katherine
dc.contributor.authorLópez-Mora, María José
dc.contributor.authorÁlvarez-Moreno, Carlos A.
dc.contributor.authorCortés, Jorge Alberto
dc.contributor.authorGarzon, Javier
dc.contributor.authorMartínez Vernaza, Samuel
dc.contributor.authorSierra-Parada, Claudia R.
dc.contributor.authorMurillo-Sarmiento, Bryan A.
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Infectologíaspa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Medicina Interna.
dc.contributor.javerianateacherGarzon, Javier
dc.coverage.cityBogotá (Colombia)spa
dc.coverage.spatialColombiaspa
dc.coverage.temporal2012-2019spa
dc.date.accessioned2023-08-31T16:21:16Z
dc.date.available2023-08-31T16:21:16Z
dc.date.created2023-03-24
dc.description.abstractenglishFungemia in hematologic malignancies (HM) has high mortality. This is a retrospective cohort of adult patients with HM and fungemia between 2012 and 2019 in institutions of Bogotá, Colombia. The epidemiological, clinical, and microbiological characteristics are described, and risk factors related to mortality are analyzed. One hundred five patients with a mean age of 48 years (SD 19.0) were identified, 45% with acute leukemia and 37% with lymphomas. In 42%, the HM was relapsed/refractory, 82% ECOG > 3, and 35% received antifungal prophylaxis; 57% were in neutropenia, with an average duration of 21.8 days. In 86 (82%) patients, Candida spp. was identified, and other yeasts in 18%. The most frequent of the isolates were non-albicans Candida (61%), C. tropicalis (28%), C. parapsilosis (17%), and C. krusei (12%). The overall 30-day mortality was 50%. The survival probability at day 30 in patients with leukemia vs. lymphoma/multiple myeloma (MM0 group was 59% (95% CI 46–76) and 41% (95% CI 29–58), p = 0.03, respectively. Patients with lymphoma or MM (HR 1.72; 95% CI 0.58–2.03) and ICU admission (HR 3.08; 95% CI 1.12–3.74) were associated with mortality. In conclusion, in patients with HM, non-albicans Candida species are the most frequent, and high mortality was identified; moreover, lymphoma or MM and ICU admission were predictors of mortality.spa
dc.description.comunidadPacientes con Neoplasias malignas hematológicasspa
dc.description.comunidadPacientes con Fungemiaspa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0001-6396-3267spa
dc.description.orcidhttps://orcid.org/0000-0001-5363-5729spa
dc.description.publindexA1spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ2spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.mdpi.com/2309-608X/9/4/400spa
dc.identifier.doihttps://doi.org/10.3390/jof9040400spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn2309-608Xspa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/65371
dc.language.isoengspa
dc.relation.citationendpage14spa
dc.relation.citationissue4spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume9spa
dc.relation.ispartofjournalJournal of Fungispa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordCandidaspa
dc.subject.keywordFungemiaspa
dc.subject.keywordHematologic malignancyspa
dc.subject.keywordCandidemiaspa
dc.subject.keywordLeukemiaspa
dc.subject.keywordLymphomaspa
dc.subject.keywordMyelomaspa
dc.subject.keywordMortalityspa
dc.titleFungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factorsspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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