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MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer

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dc.contributor.authorFernandez, Jose Nicolas
dc.contributor.authorChavarriaga, Julian
dc.contributor.authorAyala Ramírez, Paola
dc.contributor.authorPedraza, Adriana
dc.contributor.authorBolivar, John
dc.contributor.authorPrada, Juan Guillermo
dc.contributor.authorCataño Cataño, Juan Guillermo
dc.contributor.authorGarcía-Perdomo, Herney Andres
dc.contributor.authorVillanueva Congote, Juliana
dc.contributor.authorVarela, Daniela
dc.contributor.authorZarante, Ignacio
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humanaspa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Cirugía y Especialidades. Urología
dc.contributor.javerianateacherCataño Cataño, Juan Guillermo
dc.contributor.javerianateacherAyala Ramírez, Paola
dc.contributor.javerianateacherZarante, Ignacio
dc.date.accessioned2022-10-18T13:39:29Z
dc.date.available2022-10-18T13:39:29Z
dc.date.created2022-03-01
dc.description.abstractenglishPurpose: To identify micro-RNAs (miRNAs) expression profiles in peripheral blood plasma that could play a role as potential biomarkers in patients who progressed to castration-resistant prostate cancer (CRPC). Liquid biopsy analysis of miRNAs is a fast-developing field with a considerable likelihood to predict tumor progression and metastasis by targeting genes involved in oncogenesis. Patients and Methods: Differential expression analysis of miRNAs profile in CRPC patients was performed by creating small RNA libraries of circulating miRNAs using HiSeq2500 Illumina platform. A secondary analysis of aligned reads with miRNA identification and quantification was performed using miARmaSeq. Using the Bowtie algorithm, the selected variants were compared to reference nucleotide sequence GRCh38 and miRbase. Novel miRNA sequences were structurally analyzed using mirDeep2®. Results: A total of 16 patients with CRPC were included for analysis. Identified circulating miRNAs were hsa-miR-885-3p, hsa-miR -4467, hsa-miR-4686, hsa-miR-146a-3p, hsa-miR-6514-5p. Genes identified as regulated by these miRNAs were GPR56, BDNF, CTNND1, C17orf62, and DTNA. Conclusion: We explored the miRNA expression profile in patients with CRPC, identifying five miRNAs implicated in the regulation of genes involved in prostate cancer (PCa) oncogenesis and progression. We also found miRNA 855–3p in peripheral blood for the first time, which has a critical role in tumor growth mechanisms and higher expression profile than in healthy individuals.spa
dc.description.comunidadHombresspa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0002-9675-5963spa
dc.description.orcidhttps://orcid.org/0000-0002-0141-1149spa
dc.description.orcidhttps://orcid.org/0000-0001-5685-8354spa
dc.description.orcidhttps://orcid.org/0000-0001-8202-9744spa
dc.description.orcidhttps://orcid.org/0000-0002-0700-5686spa
dc.description.orcidhttps://orcid.org/0000-0002-3772-6177spa
dc.description.orcidhttps://orcid.org/0000-0002-0729-6866spa
dc.description.publindexA2spa
dc.description.quartilescopusQ3spa
dc.description.quartilewosQ3spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.dovepress.com/micrornas-as-potential-liquid-biopsy-biomarker-for-patients-with-castr-peer-reviewed-fulltext-article-RRUspa
dc.identifier.doihttps://doi.org/10.2147/RRU.S332578spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn2253-2447spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/62111
dc.language.isoengspa
dc.relation.citationendpage70spa
dc.relation.citationstartpage63spa
dc.relation.citationvolume14spa
dc.relation.ispartofjournalResearch and Reports in Urologyspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordRostatic neoplasmspa
dc.subject.keywordProstatic neoplasmsspa
dc.subject.keywordCastration-resistantspa
dc.subject.keywordMicroRNAsspa
dc.subject.keywordBiomarkersspa
dc.subject.keywordGenital neoplasmsspa
dc.subject.keywordMalespa
dc.titleMicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancerspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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