Immunomodulators released during rotavirus infectionof polarized caco-2 cells
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Data
2009-02-18Autore
Rodríguez Camacho, Luz StellaBarreto Prieto, Alfonso
Franco Cortés, Manuel Antonio
Ángel Uribe, Juanita
Autore/i aziendale
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
Tipo
Artículo de revista
ISSN
0882-8245 / 1557-8976 (Electrónico)
Pagine
163-172
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Astratto
Rotavirus preferentially replicates in enterocytes and "danger signals" released by these cells are likely to modulate viral immunity. As a model of these events, we studied selected immunomodulators released during rotavirus infection of polarized Caco-2 cells grown in transwell cultures (TW). At early time points post-infection the virus was detected mainly in the apical side of the TWs, but this tendency was progressively lost concomitantly with disruption of the cell monolayer and cell death. Rotavirus-infected cells released IL-8, PGE[sub]2, small quantities of TGF-β1, and the constitutive and inducible heat shock proteins HSC70 and HSP70, but not IL-1β, IL-6, IL-10, IL-12p70, or TNF-α. This set of immunomodulators is known to induce a non-inflammatory (non-Th-1) immune response, and may be determining, in part, the relatively low T-cell immune response observed in blood samples after RV infection.
Keywords
Caco-2 CellsLink alla risorsa
https://search-proquest-com.ezproxy.javeriana.edu.co/docview/219482764/B4E11FE1DF034B6BPQ/3?accountid=13250Editoriale
Viral Immunology; Vol. 22 Núm. 3 (2009)
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