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Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer

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dc.contributor.authorOtálora-Otálora, Beatriz Andrea
dc.contributor.authorLópez-Kleine, Liliana
dc.contributor.authorRojas, Adriana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humanaspa
dc.contributor.javerianateacherRojas, Adriana
dc.date.accessioned2023-08-28T16:16:30Z
dc.date.available2023-08-28T16:16:30Z
dc.date.created2023-01-05
dc.description.abstractenglishThe transcriptomic analysis of microarray and RNA-Seq datasets followed our own bioinformatic pipeline to identify a transcriptional regulatory network of lung cancer. Twenty-six transcription factors are dysregulated and co-expressed in most of the lung cancer and pulmonary arterial hypertension datasets, which makes them the most frequently dysregulated transcription factors. Co-expression, gene regulatory, coregulatory, and transcriptional regulatory networks, along with fibration symmetries, were constructed to identify common connection patterns, alignments, main regulators, and target genes in order to analyze transcription factor complex formation, as well as its synchronized co-expression patterns in every type of lung cancer. The regulatory function of the most frequently dysregulated transcription factors over lung cancer deregulated genes was validated with ChEA3 enrichment analysis. A Kaplan–Meier plotter analysis linked the dysregulation of the top transcription factors with lung cancer patients’ survival. Our results indicate that lung cancer has unique and common deregulated genes and transcription factors with pulmonary arterial hypertension, co-expressed and regulated in a coordinated and cooperative manner by the transcriptional regulatory network that might be associated with critical biological processes and signaling pathways related to the acquisition of the hallmarks of cancer, making them potentially relevant tumor biomarkers for lung cancer early diagnosis and targets for the development of personalized therapies against lung cancer.spa
dc.description.comunidadPacientes con Cáncer de pulmónspa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0001-8528-4433spa
dc.description.publindexA2spa
dc.description.quartilescopusQ2spa
dc.description.quartilewosQ3spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.mdpi.com/1467-3045/45/1/29spa
dc.identifier.doihttps://doi.org/10.3390/cimb45010029spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1467-3037 / 1467-3045 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/65327
dc.language.isoengspa
dc.relation.citationendpage464spa
dc.relation.citationissue1spa
dc.relation.citationstartpage434spa
dc.relation.citationvolume45spa
dc.relation.ispartofjournalCurrent Issues in Molecular Biologyspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordLung cancerspa
dc.subject.keywordPulmonary arterial hypertensionspa
dc.subject.keywordDifferentially expressed genesspa
dc.subject.keywordTranscription factorsspa
dc.subject.keywordCo-expression networksspa
dc.subject.keywordCommon connection patternsspa
dc.subject.keywordGene regulatory networkspa
dc.subject.keywordCoregulatory networkspa
dc.subject.keywordFibration symmetriesspa
dc.subject.keywordTranscriptional regulatory networkspa
dc.subject.keywordLung cancer biomarkersspa
dc.subject.keywordPatient’s survivalspa
dc.subject.keywordTranscriptomics and bioinformaticsspa
dc.titleLung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancerspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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