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Theories of Mechanically Induced Tissue Differentiation and Adaptation in the Musculoskeletal System

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dc.contributor.authorSuárez, Daniel R.
dc.date.accessioned2020-04-16T17:27:54Z
dc.date.available2020-04-16T17:27:54Z
dc.date.created2015-12-07
dc.description.abstractIt is well known that the mechanical environment affects biological tissues. The importance of theories and models that aim at explaining the role of the mechanical stimuli in process such as differentiation and adaptation of tissues is highlighted because if those theories can explain the tissue’s response to mechanical loading and to its environment, it becomes possible to predict the consequences of mechanical stimuli on growth, adaptation and aging of tissues. This review aims to present an overview of the various theories and models on tissue differentiation and adaptation, and their mathematical implementation. Although current models are numerically well defined and are able to resemble the tissue differentiation and adaptation processes, they are limited by (1) the fact that some of their input parameters are likely to be site-and species-dependent, and (2) their verification is done by data that may make the model results redundant. However, some theories do have predictive power despite the limitations of generalization. It seems to be a matter of time until new experiments and models appear with predictive power and where rigorous verification can be performed. spa
dc.description.abstractenglishIt is well known that the mechanical environment affects biological tissues. The importance of theories and models that aim at explaining the role of the mechanical stimuli in process such as differentiation and adaptation of tissues is highlighted because if those theories can explain the tissue’s response to mechanical loading and to its environment, it becomes possible to predict the consequences of mechanical stimuli on growth, adaptation and ageing of tissues. This review aims to present an overview of the various theories and models on tissue differentiation and adaptation of tissues and their mathematical implementation.Although current models are numerically well defined and are able to resemble the tissue differentiation and adaptation processes, they are limited by (1) the fact that some of their input parameters are likely to be site- and species-dependent, and (2) their verification is done by data that may make the model results redundant. However, some theories do have predictive power despite the limitations of generalization. It seems to be a matter of time until new experiments and models appear with predictive power and where rigorous verification can be performed.eng
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttp://revistas.javeriana.edu.co/index.php/iyu/article/view/11283
dc.identifier10.11144/Javeriana.iyu20-1.tmit
dc.identifier.issn2011-2769
dc.identifier.issn0123-2126
dc.identifier.urihttp://hdl.handle.net/10554/26024
dc.language.isoeng
dc.publisherPontificia Universidad Javerianaeng
dc.relation.citationissueIngenieria y Universidad; Vol 20 No 1 (2016): January-June; 21-40eng
dc.relation.citationissueIngenieria y Universidad; Vol. 20 Núm. 1 (2016): Enero-Julilo; 21-40spa
dc.relation.urihttp://revistas.javeriana.edu.co/index.php/iyu/article/view/11283/12525
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial-SinDerivadas 4.0 Internacional*
dc.titleTheories of Mechanically Induced Tissue Differentiation and Adaptation in the Musculoskeletal Systemspa
dc.title.englishTheories of mechanically induced tissue differentiation and adaptation in the musculoskeletal systemeng
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.localArtículo de revistaspa
dc.type.otherPeer-reviewed Article

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