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Detection and genotyping of HPV DNA in a group of unvaccinated young women from Colombia : baseline measures prior to future monitoring program

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dc.contributor.authorPuerto, Devi
dc.contributor.authorReyes, Viviana
dc.contributor.authorLozano, Cristina
dc.contributor.authorGarcia, Diego
dc.contributor.authorMuñoz, Nubia
dc.contributor.authorHernandez, Gustavo A.
dc.contributor.authorSanchez, Laura
dc.contributor.authorWiesner Ceballos, Carolina
dc.contributor.authorCombita, Alba
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Preventiva y Social. Grupo de investigación de Medicina Preventiva y Social
dc.contributor.javerianateacherBuitrago Ubaque, Lina Paola
dc.contributor.javerianateacherMurillo, Raul
dc.date.accessioned2020-12-05T02:50:40Z
dc.date.available2020-12-05T02:50:40Z
dc.date.created2018-07-10
dc.description.abstractenglishIn 2012, Colombia launched human papillomavirus (HPV) vaccination program for girls ages 9 to 12, and in 2013, the target age was expanded to 9 to 17 years. Monitoring the changes of HPV infection prevalence among young women has been proposed as an endpoint for early assessment of HPV vaccination programs. However, the data on HPV prevalence in young ages are very limited. The purpose of this study was to determine the prevalence of HPV infection and the distribution of genotypes in a group of nonvaccinated women ages 18 to 25 years old in three Colombian cities as baseline for the monitoring of the HPV national vaccination program. A total of 1,782 sexually active women were included. Cervical smear samples were collected to perform the Pap smear and HPV DNA detection using a Linear Array HPV assay. Of the 1,782 specimens analyzed, 60.3% were positive for any HPV type; 42.2% were positive for highrisk HPV (HR-HVP) types, and 44.4% for low-risk HPV (LR-HPV) types. Multiple and single infections were identified in 37.1% and 23.2% of samples, respectively. HR-HPV types -16, -52, and -51 were the most predominant with proportions of 11.3%, 7.92%, and 7.9%, correspondingly. The prevalence for HR-HPV 16/18 was 14.4%. HR-HPV prevalence in women with abnormal cytology (75.16%) was higher than in women with normal cytology (38.6%). In conclusion, a high prevalence of HR-HPV was observed among younger women. This HPV typespecific prevalence baseline may be used to monitor postvaccination longitudinal changes and to determine its impact on HPV-related disease incidence in Colombia population.spa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0002-0610-6477spa
dc.description.orcidhttps://orcid.org/0000-0001-7187-9946spa
dc.description.orcidhttps://orcid.org/0000-0002-3373-1809spa
dc.description.orcidhttps://orcid.org/0000-0001-6295-7316spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ2spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://cancerpreventionresearch.aacrjournals.org/content/11/9/581spa
dc.identifier.doihttps://doi.org/10.1158/1940-6207.CAPR-17-0439spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1940-6207 / 1940-6215 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/51931
dc.language.isoengspa
dc.relation.citationendpage592spa
dc.relation.citationissue9spa
dc.relation.citationstartpage581spa
dc.relation.citationvolume11spa
dc.relation.ispartofjournalCancer Prevention Researchspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleDetection and genotyping of HPV DNA in a group of unvaccinated young women from Colombia : baseline measures prior to future monitoring programspa
dc.type.coarhttp://purl.org/coar/resource_type/c_dcae04bcspa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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