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Juvenile polyautoimmunity in a rheumatology setting

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dc.contributor.authorMalagón, Clara
dc.contributor.authorDel Pilar Gomez, Maria
dc.contributor.authorMosquera, Catalina
dc.contributor.authorVargas, Camilo
dc.contributor.authorGonzalez, Tatiana
dc.contributor.authorArango, Cristine
dc.contributor.authorPerez, Pilar
dc.contributor.authorAmaya Uribe, Laura
dc.contributor.authorMolano Gonzalez, Nicolas
dc.contributor.authorAnaya, Juan Manuel
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Pediatría. Grupo de Investigación de la Mujer y de la Infancia (GIMI)
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Pediatría
dc.contributor.javerianateacherMartin, Lorena
dc.date.accessioned2020-12-02T12:39:52Z
dc.date.available2020-12-02T12:39:52Z
dc.date.created2019
dc.description.abstractenglishOvert polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics. A hierarchical cluster analysis was done to determine similarities between autoimmune diseases based on PolyA. PolyA occurred simultaneously in 138 (44%) patients. Multiple autoimmune syndrome was observed in 62 (19.8%) patients. There were 25 index diseases of which, systemic lupus erythematosus (SLE, n = 134, 42.8%), juvenile idiopathic arthritis (JIA, n = 40, 12.7%), Hashimoto's thyroiditis (HT, n = 24, 7.66%), immune thrombocytopenic purpura (ITP n = 20, 6.39%), antiphospholipid syndrome (APS, n = 15, 4.79%), and vitiligo (VIT, n = 15, 4.79%) were the most frequent and represented 79.23% of the total number of patients. Familial autoimmunity influenced PolyA. A high aggregation of autoimmunity was observed (λr = 3.5). Three main clusters were identified, of which SLE and APS were the most similar pair of diseases (based on the Jaccard index) followed by HT and JIA, which were related to ITP and Sjögren's syndrome. The third cluster was composed of localized scleroderma and VIT. Our findings may assist physicians to make an early diagnosis of this frequent condition. Pediatric patients with ADs should be systematically assessed for PolyA.spa
dc.description.comunidadPaciente jovenspa
dc.description.indexingRevista Nacional - Indexadaspa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=30772494&lang=es&site=eds-livespa
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2018.11.006spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1568-9972 / 18730183 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/51867
dc.language.isoengspa
dc.relation.citationendpage381spa
dc.relation.citationissue4spa
dc.relation.citationstartpage369spa
dc.relation.citationvolume18spa
dc.relation.ispartofjournalAutoimmunity Reviewsspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordPolyautoimmunityspa
dc.subject.keywordJuvenile patientsspa
dc.subject.keywordAutoimmune tautologyspa
dc.subject.keywordSystemic lupus erythematousspa
dc.subject.keywordJuvenile idiopathic arthritisspa
dc.titleJuvenile polyautoimmunity in a rheumatology settingspa
dc.type.coarhttp://purl.org/coar/resource_type/c_1843spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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