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Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study

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dc.contributor.authorOlaya-Galán, Nury N.
dc.contributor.authorSalas-Cárdenas, Sandra P.
dc.contributor.authorRodriguez-Sarmiento, Jorge L.
dc.contributor.authorIbáñez-Pinilla, Milcíades
dc.contributor.authorMonroy, Ricardo
dc.contributor.authorCorredor-Figueroa, Adriana P.
dc.contributor.authorRubiano, Wilson
dc.contributor.authorDe la Peña, Jairo
dc.contributor.authorShen, HuaMin
dc.contributor.authorBuehring, Gertrude C.
dc.contributor.authorPatarroyo, Manuel A.
dc.contributor.authorGutierrez, Maria F.
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patologíaspa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Hospital Universitario San Ignaciospa
dc.contributor.javerianateacherRodriguez-Sarmiento, Jorge L.
dc.coverage.spatialColombiaspa
dc.date.accessioned2022-06-14T12:14:53Z
dc.date.available2022-06-14T12:14:53Z
dc.date.created2021-09
dc.description.abstractenglishViruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order to initiate cancer disease. In efforts to establish a causative role of viruses, first is needed to demonstrate the strength and consistency of associations in different populations. The aim of this study was to determine the association of bovine leukemia virus (BLV), a causative agent of leukemia in cattle, with breast cancer and its biomarkers used as prognosis of the severity of the disease (Ki67, HER2, hormonal receptors) in Colombian women. An unmatched, observational case–control study was conducted among women undergoing breast surgery between 2016–2018. Malignant samples (n = 75) were considered as cases and benign samples (n = 83) as controls. Nested-liquid PCR, in-situ PCR and immunohistochemistry were used for viral detection in blood and breast tissues. For the risk assessment, only BLV positive samples from breast tissues were included in the analysis. BLV was higher in cases group (61.3%) compared with controls (48.2%), with a statistically significant association between the virus and breast cancer in the unconditional logistic regression (adjusted-OR = 2.450,95%CI:1.088–5.517, p = 0.031). In this study, BLV was found in both blood and breast tissues of participants and an association between breast cancer and the virus was confirmed in Colombia, as an intermediate risk factor.spa
dc.description.esciSispa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0002-0084-0339spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ2spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257492spa
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0257492spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1932-6203spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/60271
dc.language.isoengspa
dc.relation.citationendpage18spa
dc.relation.citationissue9spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume16spa
dc.relation.ispartofjournalPLoS ONEspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleRisk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control studyspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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