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Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study

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dc.contributor.authorRiveros-Rivera, Alain
dc.contributor.authorPenzel, Thomas
dc.contributor.authorGunga, Hanns-Christian
dc.contributor.authorOpatz, Oliver
dc.contributor.authorPaul, Friedemann
dc.contributor.authorKlug, Lars
dc.contributor.authorBoschmann, Michael
dc.contributor.authorMähler, Anja
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicasspa
dc.contributor.javerianateacherRiveros-Rivera, Alain
dc.coverage.cityBerlín (Alemania)spa
dc.coverage.spatialAlemaniaspa
dc.coverage.temporal2019-2020
dc.date.accessioned2023-03-14T14:24:30Z
dc.date.available2023-03-14T14:24:30Z
dc.date.created2022-05-24
dc.description.abstractenglishContext: The use of daytime napping as a countermeasure in sleep disturbances has been recommended but its physiological evaluation at high altitude is limited. Objective: To evaluate the neuroendocrine response to hypoxic stress during a daytime nap and its cognitive impact. Design, Subject, and Setting: Randomized, single-blind, three period cross-over pilot study conducted with 15 healthy lowlander subjects (8 women) with a mean (SD) age of 29(6) years (Clinicaltrials identifier: NCT04146857, https://clinicaltrials.gov/ct2/show/NCT04146857?cond=napping&draw=3&rank=12). Interventions: Volunteers underwent a polysomnography, hematological and cognitive evaluation around a 90 min midday nap, being allocated to a randomized sequence of three conditions: normobaric normoxia (NN), normobaric hypoxia at FiO2 14.7% (NH15) and 12.5% (NH13), with a washout period of 1 week between conditions. Results: Primary outcome was the interbeat period measured by the RR interval with electrocardiogram. Compared to normobaric normoxia, RR during napping was shortened by 57 and 206 ms under NH15 and NH13 conditions, respectively (p < 0.001). Sympathetic predominance was evident by heart rate variability analysis and increased epinephrine levels. Concomitantly, there were significant changes in endocrine parameters such as erythropoietin (∼6 UI/L) and cortisol (∼100 nmol/L) (NH13 vs. NN, p < 0.001). Cognitive evaluation revealed changes in the color-word Stroop test. Additionally, although sleep efficiency was preserved, polysomnography showed lesser deep sleep and REM sleep, and periodic breathing, predominantly in men. Conclusion: Although napping in simulated altitude does not appear to significantly affect cognitive performance, sex-dependent changes in cardiac autonomic modulation and respiratory pattern should be considered before napping is prescribed as a countermeasure.spa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0002-0011-0758spa
dc.description.publindexA1spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.frontiersin.org/articles/10.3389/fphys.2022.899636/fullspa
dc.identifier.doihttps://doi.org/10.3389/fphys.2022.899636spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1664-042Xspa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/63757
dc.language.isoengspa
dc.relation.citationendpage14spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume13spa
dc.relation.ispartofjournalFrontiers in Physiologyspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.source.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordNappingspa
dc.subject.keywordSleepspa
dc.subject.keywordHypoxiaspa
dc.subject.keywordHigh altitude (low air pressure)spa
dc.subject.keywordAutonomic nervous systemspa
dc.subject.keywordPhysiological stressspa
dc.titleHypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot studyspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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