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Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals

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dc.contributor.authorBautista, Diana
dc.contributor.authorRomero-Sanchez, Consuelo
dc.contributor.authorFranco Cortes, Manuel Antonio
dc.contributor.authorAngel, Juana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humanaspa
dc.contributor.javerianateacherFranco Cortes, Manuel Antonio
dc.contributor.javerianateacherAngel, Juana
dc.date.accessioned2023-08-28T15:42:52Z
dc.date.available2023-08-28T15:42:52Z
dc.date.created2023-03-21
dc.description.abstractenglishBackground: In humans, blood circulating IgM+IgD+CD27+ B cells are considered analogous to those described in the marginal zone of the spleen and are involved in important immunological processes. The homing receptors they express, and the organs involved in their development (for example, intestinal organs in rabbits) are only partially known. We recently reported that this population is heterogeneous and composed of at least two subsets: one expressing high levels of IgM – IgMhi B cells – and another low levels – IgMlo B cells. Objectives: To evaluate the expression of homing receptors on IgD+CD27+ IgMhi and IgMlo B cells and quantify their frequencies in blood of control and appendectomized and/or tonsillectomized volunteers. Materials and Methods: Using spectral flow cytometry, the simultaneous expression of 12 previously reported markers that differentiate IgMhi B cells and IgMlo B cells and of α4β7, CCR9, CD22 and CCR10 were evaluated in blood circulating B cells of control and appendectomized and/or tonsillectomized volunteers. Results The existence of phenotypically defined IgMlo and IgMhi B cell subsets was confirmed. They differentially expressed intestinal homing receptors, and the expression of α4β7 and CCR9 seems to determine new IgM subpopulations. IgMlo and IgMhi B cells were detected at lower frequencies in the appendectomized and/or tonsillectomized volunteers relative to controls. Conclusions: Human blood circulating IgD+CD27+ IgMlo and IgMhi B cell subsets differentially express homing receptors, and it is necessary to investigate if mucosal organs are important in their development.spa
dc.description.comunidadPacientes apendicectomizados y/o amigdalectomizadosspa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0002-0817-2718spa
dc.description.orcidhttps://orcid.org/0000-0002-6973-7639spa
dc.description.orcidhttps://orcid.org/0000-0002-0265-0563spa
dc.description.orcidhttps://orcid.org/0000-0001-6623-5337spa
dc.description.publindexA2spa
dc.description.quartilescopusQ3spa
dc.description.quartilewosQ4spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://search-ebscohost-com.ezproxy.javeriana.edu.co/login.aspx?direct=true&AuthType=sso&db=edselc&AN=edselc.2-52.0-85150865978&lang=es&site=eds-live&scope=site&custid=s6670599spa
dc.identifier.doihttps://doi.org/10.1080/08820139.2023.2187303spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn0882-0139 / 1532-4311 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/65323
dc.language.isoengspa
dc.relation.citationendpage453spa
dc.relation.citationissue4spa
dc.relation.citationstartpage439spa
dc.relation.citationvolume52spa
dc.relation.ispartofjournalImmunological Investigationsspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordAppendectomyspa
dc.subject.keywordHoming receptorsspa
dc.subject.keywordMarginal zone B cellsspa
dc.subject.keywordSpectral flow cytometryspa
dc.subject.keywordTonsillectomyspa
dc.titleExpression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individualsspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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