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Neurostimulation therapy for non-neurogenic overactive bladder in children : a meta-analysis

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dc.contributor.authorFernández Bonilla, José Nicolas
dc.contributor.authorChua, Michael E.
dc.contributor.authorMing, Jessica M.
dc.contributor.authorSilangcruz, Jan Michael
dc.contributor.authorZu'bi, Fadi
dc.contributor.authorDos Santos, Joana
dc.contributor.authorLorenzo, Armando J.
dc.contributor.authorBraga, Luis H.
dc.contributor.authorIglesias Lopes, Roberto
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Cirugía y Especialidades. Grupo de Investigación de Cirugía y Especialidades
dc.date.accessioned2020-06-02T22:01:21Z
dc.date.available2020-06-02T22:01:21Z
dc.date.created2017
dc.description.abstractenglishObjective: To assess the efficacy and safety of neurostimulation for non-neurogenic overactive bladder in children, we conducted a meta-analysis of randomized controlled trials (RCTs). Materials and methods: A systematic literature search was performed on August 2016. RCTs were evaluated according to the Cochrane Collaboration risk of bias assessment. Number of patients with post-treatment partial response (PR) (50%-89%), complete response (CR) (≥90%), and full response (FR) (100%) were extracted for relative risk (RR) and 95% confidence interval (CI). Effect estimates were pooled using the Mantel-Haenszel method with random effect model if significant inter-study heterogeneity (P <.1) was noted. Subgroup analysis was performed according to each treatment setting (PROSPERO CRD42016043502). Results: Five eligible studies (245 patients) were included. Overall effect estimates showed that compared with standard urotherapy, neurostimulation demonstrated significantly better ≥50% (PR + CR + FR) response (RR = 2.8, 95% CI 1.1-7.2), but not ≥90% (CR + FR) response (RR = 8.28, 95% CI 0.65-105.92). Clinic-based neurostimulation had significantly better treatment outcomes for both ≥50% (PR + CR + FR) and ≥90% (CR + FR) responses (RR = 3.24, 95% CI 1.89-5.57; RR = 20.81, 95% CI 2.97-145.59, respectively), whereas a self-administered regimen showed no differences for both ≥50% (PR + CR + FR) and ≥90% (CR + FR) response rates between treatment groups (RR = 2.61, 95% CI 0.48-14.15; RR = 3.55, 95% CI 0.19-67.82, respectively). No serious adverse events were reported. Conclusion: Neurostimulation therapy may lead to better partial improvement of non-neurogenic overactive bladder; however, it may not render a definitive complete response. Office-based neurostimulation seems more efficacious than self-administered neurostimulation. Further RCTs are needed to compare outcomes of the 2 regimens.spa
dc.description.paginas201-207spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ3spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0090429517307987?via%3Dihubspa
dc.identifier.doihttps://doi.org/10.1016/j.urology.2017.08.003spa
dc.identifier.issn0090-4295 / 1527-9995 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/49579
dc.languagespaspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceUrology; Vol. 110 (2017)spa
dc.titleNeurostimulation therapy for non-neurogenic overactive bladder in children : a meta-analysisspa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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