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Brain network organization and social executive performance in frontotemporal dementia

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dc.contributor.authorSedeño, Lucas
dc.contributor.authorCouto, Blas
dc.contributor.authorGarcía-Cordero, Indira
dc.contributor.authorMelloni, Margherita
dc.contributor.authorBaez, Sandra
dc.contributor.authorMorales Sepúlveda, Juan Pablo
dc.contributor.authorFraiman, Daniel
dc.contributor.authorHuepe, David
dc.contributor.authorHurtado, Esteban
dc.contributor.authorMatallana, Diana
dc.contributor.authorKuljis, Rodrigo
dc.contributor.authorTorralva, Teresa
dc.contributor.authorChialvo, Dante
dc.contributor.authorSigman, Mariano
dc.contributor.authorPiguet, Olivier
dc.contributor.authorManes, Facundo
dc.contributor.authorIbanez, Agustin
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
dc.date.accessioned2020-05-14T17:17:46Z
dc.date.available2020-05-14T17:17:46Z
dc.date.created2016-02-18
dc.description.abstractenglishOBJECTIVES: Behavioral variant frontotemporal dementia (bvFTD) is characterized by early atrophy in the frontotemporoinsular regions. These regions overlap with networks that are engaged in social cognition-executive functions, two hallmarks deficits of bvFTD. We examine (i) whether Network Centrality (a graph theory metric that measures how important a node is in a brain network) in the frontotemporoinsular network is disrupted in bvFTD, and (ii) the level of involvement of this network in social-executive performance. METHODS: Patients with probable bvFTD, healthy controls, and frontoinsular stroke patients underwent functional MRI resting-state recordings and completed social-executive behavioral measures. RESULTS: Relative to the controls and the stroke group, the bvFTD patients presented decreased Network Centrality. In addition, this measure was associated with social cognition and executive functions. To test the specificity of these results for the Network Centrality of the frontotemporoinsular network, we assessed the main areas from six resting-state networks. No group differences or behavioral associations were found in these networks. Finally, Network Centrality and behavior distinguished bvFTD patients from the other groups with a high classification rate. CONCLUSIONS: bvFTD selectively affects Network Centrality in the frontotemporoinsular network, which is associated with high-level social and executive profile.spa
dc.description.paginas250-262spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ2spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/26888621ation-and-social-executive-performance-in-frontotemporal-dementia/7EEE01360980E90D69F5E30CDA37E5C3spa
dc.identifier.doihttps://doi.org/10.1017/S1355617715000703spa
dc.identifier.issn1355-6177 / 1469-7661 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/49238
dc.languagespaspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceJournal of the International Neuropsychological Society; Vol. 22 Esp. (2016)spa
dc.subject.keywordFunctional connectivityspa
dc.subject.keywordGraph theory analysisspa
dc.subject.keywordFrontoinsularstrokespa
dc.subject.keywordNeurodegenerative diseasespa
dc.subject.keywordf MRI resting-statespa
dc.subject.keywordNode centralityspa
dc.titleBrain network organization and social executive performance in frontotemporal dementiaspa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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