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Identification and characterization at the single-cell level of cytokine-producing circulating cells in children with dengue

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dc.contributor.authorPerdomo Celis, Federico
dc.contributor.authorRomero, Felipe
dc.contributor.authorSalgado García, Doris Martha Cecilia
dc.contributor.authorVega Vega, Martha Rocio
dc.contributor.authorRodríguez Rodríguez, Jairo Antonio
dc.contributor.authorAngel, Juana
dc.contributor.authorFranco Cortes, Manuel Antonio
dc.contributor.authorGreenberg, Harry B.
dc.contributor.authorNarváez Rojas, Carlos Fernando
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
dc.contributor.javerianateacherAngel, Juana
dc.contributor.javerianateacherFranco Cortes, Manuel Antonio
dc.coverage.departmentHuila (Colombia)spa
dc.coverage.spatialColombiaspa
dc.coverage.temporal2013-2015
dc.date.accessioned2020-03-04T21:33:32Z
dc.date.accessioned2020-04-15T13:34:59Z
dc.date.available2020-03-04T21:33:32Z
dc.date.available2020-04-15T13:34:59Z
dc.date.created2018-01-30
dc.description.abstractenglishIn this study, we identified, at the single-cell level, naturally induced cytokine-producing circulating cells (CPCCs) in children with dengue virus (DENV) infection ranging clinically from mild to severe disease. Tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) CPCCs were detected in children with primary or secondary acute dengue virus (DENV) infection, and the pattern of these cytokines was similar to that seen in the supernatant of cultured peripheral blood mononuclear cells and partially comparable to that found in plasma. Monocytes, B cells, and myeloid dendritic cells (mDCs) were the primary CPCCs detected, and the frequency of mDCs was significantly higher in severe disease. B cells isolated from children with dengue spontaneously secreted TNF-α, IL-6, and interleukin 10, and supernatants from cultures of purified B cells induced activation of allogeneic T cells, supporting an antibody-independent function of these cells during DENV infection. Thus, CPCCs could be a new immune parameter with potential use to evaluate pathogenesis in this infection.spa
dc.description.comunidadNiños con Denguespa
dc.description.indexingRevista Internacional - Indexada
dc.description.orcidhttps://orcid.org/0000-0001-6623-5337
dc.description.orcidhttps://orcid.org/0000-0002-0265-0563
dc.description.paginas1472-1480spa
dc.description.publindexA1
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.description.tipoarticuloCompletospa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://academic.oup.com/jid/article/217/9/1472/4829654spa
dc.identifier.doihttps://doi.org/10.1093/infdis/jiy053spa
dc.identifier.issn0022-1899 / 1537-6613 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/47470
dc.languageengspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceJournal of Infectious Diseases; Volumen 217 Número 9 (2018)spa
dc.subject.keywordDenguespa
dc.subject.keywordMonocytesspa
dc.subject.keywordB cellsspa
dc.subject.keywordIL-6spa
dc.subject.keywordTNF-αspa
dc.titleIdentification and characterization at the single-cell level of cytokine-producing circulating cells in children with denguespa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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