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Medical challenge posed by retroperitoneal fibrosis : case reports and literature review

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dc.contributor.authorCervera Bonilla, Sergio
dc.contributor.authorGarcía Mora, Mauricio
dc.contributor.authorRodríguez Ossa, Paola
dc.contributor.authorMessa, Oscar
dc.contributor.authorMendoza Díaz, Sara
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
dc.date.accessioned2021-03-20T04:18:32Z
dc.date.available2021-03-20T04:18:32Z
dc.date.created2020-01-10
dc.description.abstractenglishIdiopathic retroperitoneal fibrosis (RPF) is a rare fibro-inflammatory disease, with a low incidence worldwide, which occurs around the abdominal aorta and the iliac arteries. It spreads through the retroperitoneum causing ureteral obstruction with associated renal failure and obstruction of other adjacent structures. RPF can be idiopathic or secondary to neoplastic processes, infections, or medications. RPF is considered part of the spectrum of the disease related to immunoglobulin G4 (IgG4) and other autoimmune disorders. Occupational exposure to asbestos and tobacco smoke are important risk factors for the development of idiopathic RPF. The clinical picture is nonspecific, from pain to symptoms due to ureteral compression, this being the main complication associated. Imaging studies are essential in the diagnosis; computed tomography (CT) and magnetic resonance imaging (MRI) are the most reliable imaging modalities. The goal of treatment is to stop the progression of the fibroinflammatory reaction. The first line of treatment is usually with medical management. Biological agents, such as rituximab and infliximab, have also been used, even with scarce data in the literature. Surgery is usually performed to improve a ureteral obstruction and should always be accompanied by systemic steroid treatment. The conservative approach given by systemic therapy and ureteral stent placement or nephrostomies has been recommended, thus reserving surgical treatment for refractory cases. We present two clinical cases of idiopathic RPF, one of them associated with IgG4.spa
dc.description.indexingN/Aspa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=32064203&lang=es&site=eds-livespa
dc.identifier.doihttps://doi.org/10.7759/cureus.6624spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn2168-8184 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/53310
dc.language.isoengspa
dc.relation.citationendpage9spa
dc.relation.citationissue1spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume12spa
dc.relation.ispartofjournalCureusspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordFibrosis retroperitonealspa
dc.subject.keywordIdiopathicspa
dc.subject.keywordIgg4spa
dc.titleMedical challenge posed by retroperitoneal fibrosis : case reports and literature reviewspa
dc.type.coarhttp://purl.org/coar/resource_type/c_93fcspa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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